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• W2056539306 abstract "• Lutein is efficiently encapsulated into α -polymorphic LMWC nanoparticles. • NMR studies show weak interaction between lutein & LMWC in presence of water. • Lutein absorption was higher from nanoencapsules than mixed micelles. • Lutein nanoencapsules can serve as nanofood for improving better health benefits. This study aims to develop water-soluble low molecular weight chitosan (LMWC) nanoencapsules with lutein to improve its bioavailability. Lutein-LMWC nanoencapsules were prepared, characterized and bioavailability was studied in vitro and in vivo with lutein in mixed micelles (control). The particle size ranged between 80–600 nm, which was confirmed by Atomic Force Microscope. The interaction between LMWC and lutein in nanocencapsules by 1 H and 13 C NMR showed the essentiality of water molecules to hold the lutein between LMWC chains of nanoparticle with a reversible weak bond. Bioavailability of lutein (200 μM) in vitro showed that lutein-LMWC nanoencapsules was significantly higher (27.7%) than control. Postprandial lutein level in the plasma (54.5%), liver (53.9%) and eyes (62.8%) of mice fed on nanoencapsulated lutein were higher than the control. LMWC may serve as novel carrier for enhancing the lutein bioavailability and can be suggested as the better dietary compound in food and pharmaceutical applications." @default.
• W2056539306 created "2016-06-24" @default.
• W2056539306 creator A5030310075 @default.
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• W2056539306 date "2013-11-01" @default.
• W2056539306 modified "2023-09-30" @default.
• W2056539306 title "Promising interaction between nanoencapsulated lutein with low molecular weight chitosan: Characterization and bioavailability of lutein in vitro and in vivo" @default.
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• W2056539306 doi "https://doi.org/10.1016/j.foodchem.2013.02.108" @default.
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