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- W2056540233 endingPage "e0124295" @default.
- W2056540233 startingPage "e0124295" @default.
- W2056540233 abstract "Cholecystokinin (CCK), a peptide hormone and one of the most abundant neuropeptides in vertebrate brain, mediates its actions via two G-protein coupled receptors, CCKAR and CCKBR, respectively active in peripheral organs and the central nervous system. Here, we demonstrate that the CCK receptors have a dynamic and largely reciprocal expression in embryonic and postnatal brain. Using compound homozygous mutant mice lacking the activity of both CCK receptors, we uncover their additive, functionally synergistic effects in brain development and demonstrate that CCK receptor loss leads to abnormalities of cortical development, including defects in the formation of the midline and corpus callosum, and cortical interneuron migration. Using comparative transcriptome analysis of embryonic neocortex, we define the molecular mechanisms underlying these defects. Thus we demonstrate a developmental, hitherto unappreciated, role of the two CCK receptors in mammalian neocortical development." @default.
- W2056540233 created "2016-06-24" @default.
- W2056540233 creator A5013113053 @default.
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- W2056540233 creator A5055131358 @default.
- W2056540233 creator A5080417818 @default.
- W2056540233 date "2015-04-15" @default.
- W2056540233 modified "2023-10-18" @default.
- W2056540233 title "Functional Synergy between Cholecystokinin Receptors CCKAR and CCKBR in Mammalian Brain Development" @default.
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