Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056541049> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2056541049 endingPage "341" @default.
- W2056541049 startingPage "335" @default.
- W2056541049 abstract "Androgen receptor (AR) and kallikrein (KLK-2) regulates the PSA (prostate specific antigen) transcription and activation, respectively. We investigated the individual and combined risk of KLK-2, PSA and AR gene polymorphism in histologically confirmed CaP patients and healthy controls from north India. DNA was extracted from peripheral blood leucocytes pellet of 277 subjects. AR repeats analysis was done by PCR-Genscan method. PSA and KLK-2 were genotyped by PCR-RFLP method. Kruskal–Wallis test and logistic regression was applied for mean comparison and risk determination. A significant association for CaP risk was observed with short AR-CAG repeats (OR = 3.36, p < 0.001) and CC genotype of KLK-2 (OR = 2.78, p = 0.031), however, no association was found with PSA and AR-GGN repeat polymorphism. PSA/GG genotype was significantly associated with higher Gleason score (≥7) of tumor (OR = 6.23, p < 0.01). No association was observed with other confounding variables such as PSA and age with any of these polymorphisms. Thus, we hypothesize that these polymorphisms may influence the etiology of CaP and may have the probability to become appropriate marker either independently or in combination. The combined information on serum PSA level, PSA (G/A), KLK-2 (C/T) genotypes and AR (CAG; GGN repeat) may assist in the deterrence of unnecessary biopsies." @default.
- W2056541049 created "2016-06-24" @default.
- W2056541049 creator A5014548378 @default.
- W2056541049 creator A5033846510 @default.
- W2056541049 creator A5049932826 @default.
- W2056541049 creator A5069150930 @default.
- W2056541049 creator A5080208431 @default.
- W2056541049 date "2007-04-01" @default.
- W2056541049 modified "2023-10-17" @default.
- W2056541049 title "Is there an inter-relationship between prostate specific antigen, kallikrein-2 and androgen receptor gene polymorphisms with risk of prostate cancer in north Indian population?" @default.
- W2056541049 cites W1976706733 @default.
- W2056541049 cites W2020636054 @default.
- W2056541049 cites W2027066393 @default.
- W2056541049 cites W2027830460 @default.
- W2056541049 cites W2029540269 @default.
- W2056541049 cites W2041963102 @default.
- W2056541049 cites W2050956272 @default.
- W2056541049 cites W2057910576 @default.
- W2056541049 cites W2085194185 @default.
- W2056541049 cites W2096277507 @default.
- W2056541049 cites W2096368473 @default.
- W2056541049 cites W2107790140 @default.
- W2056541049 cites W2118094114 @default.
- W2056541049 cites W2123296725 @default.
- W2056541049 cites W2134235648 @default.
- W2056541049 cites W2159227526 @default.
- W2056541049 cites W2166728295 @default.
- W2056541049 doi "https://doi.org/10.1016/j.steroids.2006.12.004" @default.
- W2056541049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17257635" @default.
- W2056541049 hasPublicationYear "2007" @default.
- W2056541049 type Work @default.
- W2056541049 sameAs 2056541049 @default.
- W2056541049 citedByCount "20" @default.
- W2056541049 countsByYear W20565410492012 @default.
- W2056541049 countsByYear W20565410492013 @default.
- W2056541049 countsByYear W20565410492014 @default.
- W2056541049 countsByYear W20565410492016 @default.
- W2056541049 countsByYear W20565410492017 @default.
- W2056541049 crossrefType "journal-article" @default.
- W2056541049 hasAuthorship W2056541049A5014548378 @default.
- W2056541049 hasAuthorship W2056541049A5033846510 @default.
- W2056541049 hasAuthorship W2056541049A5049932826 @default.
- W2056541049 hasAuthorship W2056541049A5069150930 @default.
- W2056541049 hasAuthorship W2056541049A5080208431 @default.
- W2056541049 hasConcept C104317684 @default.
- W2056541049 hasConcept C121608353 @default.
- W2056541049 hasConcept C126322002 @default.
- W2056541049 hasConcept C135763542 @default.
- W2056541049 hasConcept C143998085 @default.
- W2056541049 hasConcept C151956035 @default.
- W2056541049 hasConcept C203014093 @default.
- W2056541049 hasConcept C2776235491 @default.
- W2056541049 hasConcept C2780192828 @default.
- W2056541049 hasConcept C2781406297 @default.
- W2056541049 hasConcept C2908647359 @default.
- W2056541049 hasConcept C54355233 @default.
- W2056541049 hasConcept C61367390 @default.
- W2056541049 hasConcept C71924100 @default.
- W2056541049 hasConcept C77350462 @default.
- W2056541049 hasConcept C86803240 @default.
- W2056541049 hasConcept C99454951 @default.
- W2056541049 hasConceptScore W2056541049C104317684 @default.
- W2056541049 hasConceptScore W2056541049C121608353 @default.
- W2056541049 hasConceptScore W2056541049C126322002 @default.
- W2056541049 hasConceptScore W2056541049C135763542 @default.
- W2056541049 hasConceptScore W2056541049C143998085 @default.
- W2056541049 hasConceptScore W2056541049C151956035 @default.
- W2056541049 hasConceptScore W2056541049C203014093 @default.
- W2056541049 hasConceptScore W2056541049C2776235491 @default.
- W2056541049 hasConceptScore W2056541049C2780192828 @default.
- W2056541049 hasConceptScore W2056541049C2781406297 @default.
- W2056541049 hasConceptScore W2056541049C2908647359 @default.
- W2056541049 hasConceptScore W2056541049C54355233 @default.
- W2056541049 hasConceptScore W2056541049C61367390 @default.
- W2056541049 hasConceptScore W2056541049C71924100 @default.
- W2056541049 hasConceptScore W2056541049C77350462 @default.
- W2056541049 hasConceptScore W2056541049C86803240 @default.
- W2056541049 hasConceptScore W2056541049C99454951 @default.
- W2056541049 hasIssue "4" @default.
- W2056541049 hasLocation W20565410491 @default.
- W2056541049 hasLocation W20565410492 @default.
- W2056541049 hasOpenAccess W2056541049 @default.
- W2056541049 hasPrimaryLocation W20565410491 @default.
- W2056541049 hasRelatedWork W1864918391 @default.
- W2056541049 hasRelatedWork W1984464970 @default.
- W2056541049 hasRelatedWork W2071753433 @default.
- W2056541049 hasRelatedWork W2088520467 @default.
- W2056541049 hasRelatedWork W2131077462 @default.
- W2056541049 hasRelatedWork W2611803138 @default.
- W2056541049 hasRelatedWork W2888003396 @default.
- W2056541049 hasRelatedWork W3111390827 @default.
- W2056541049 hasRelatedWork W4295900113 @default.
- W2056541049 hasRelatedWork W4387341186 @default.
- W2056541049 hasVolume "72" @default.
- W2056541049 isParatext "false" @default.
- W2056541049 isRetracted "false" @default.
- W2056541049 magId "2056541049" @default.
- W2056541049 workType "article" @default.