FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056541759> ?p ?o ?g. }

• W2056541759 endingPage "342" @default.
• W2056541759 startingPage "334" @default.
• W2056541759 abstract "Autism spectrum disorder (ASD) is a neurodevelopmental disorder, of which Asperger syndrome and high-functioning autism are subtypes. Our goal is: 1) to determine whether a diagnostic model based on single-nucleotide polymorphisms (SNPs), brain regional thickness measurements, or brain regional volume measurements can distinguish Asperger syndrome from high-functioning autism; and 2) to compare the SNP, thickness, and volume-based diagnostic models. Our study included 18 children with ASD: 13 subjects with high-functioning autism and 5 subjects with Asperger syndrome. For each child, we obtained 25 SNPs for 8 ASD-related genes; we also computed regional cortical thicknesses and volumes for 66 brain structures, based on structural magnetic resonance (MR) examination. To generate diagnostic models, we employed five machine-learning techniques: decision stump, alternating decision trees, multi-class alternating decision trees, logistic model trees, and support vector machines. For SNP-based classification, three decision-tree-based models performed better than the other two machine-learning models. The performance metrics for three decision-tree-based models were similar: decision stump was modestly better than the other two methods, with accuracy = 90%, sensitivity = 0.95 and specificity = 0.75. All thickness and volume-based diagnostic models performed poorly. The SNP-based diagnostic models were superior to those based on thickness and volume. For SNP-based classification, rs878960 in GABRB3 (gamma-aminobutyric acid A receptor, beta 3) was selected by all tree-based models. Our analysis demonstrated that SNP-based classification was more accurate than morphometry-based classification in ASD subtype classification. Also, we found that one SNP—rs878960 in GABRB3—distinguishes Asperger syndrome from high-functioning autism." @default.
• W2056541759 created "2016-06-24" @default.
• W2056541759 creator A5025273851 @default.
• W2056541759 creator A5027220663 @default.
• W2056541759 creator A5028868027 @default.
• W2056541759 creator A5032249239 @default.
• W2056541759 creator A5044757881 @default.
• W2056541759 creator A5074569952 @default.
• W2056541759 creator A5088596691 @default.
• W2056541759 date "2011-12-01" @default.
• W2056541759 modified "2023-10-18" @default.
• W2056541759 title "Predictive models for subtypes of autism spectrum disorder based on single-nucleotide polymorphisms and magnetic resonance imaging" @default.
• W2056541759 cites W1505479281 @default.
• W2056541759 cites W1557418592 @default.
• W2056541759 cites W1564634668 @default.
• W2056541759 cites W1980309199 @default.
• W2056541759 cites W1981039744 @default.
• W2056541759 cites W1985812867 @default.
• W2056541759 cites W1993383520 @default.
• W2056541759 cites W2000275043 @default.
• W2056541759 cites W2002371359 @default.
• W2056541759 cites W2005342778 @default.
• W2056541759 cites W2023642217 @default.
• W2056541759 cites W2024107088 @default.
• W2056541759 cites W2026473386 @default.
• W2056541759 cites W2035027696 @default.
• W2056541759 cites W2036455526 @default.
• W2056541759 cites W2062652106 @default.
• W2056541759 cites W2085736898 @default.
• W2056541759 cites W2088667804 @default.
• W2056541759 cites W2092630887 @default.
• W2056541759 cites W2097449522 @default.
• W2056541759 cites W2098721803 @default.
• W2056541759 cites W2098914660 @default.
• W2056541759 cites W2104787607 @default.
• W2056541759 cites W2107228680 @default.
• W2056541759 cites W2113319997 @default.
• W2056541759 cites W2124423779 @default.
• W2056541759 cites W2127324977 @default.
• W2056541759 cites W2131553051 @default.
• W2056541759 cites W2133298971 @default.
• W2056541759 cites W2139092938 @default.
• W2056541759 cites W2141265734 @default.
• W2056541759 cites W2145055578 @default.
• W2056541759 cites W2150135217 @default.
• W2056541759 cites W2151499551 @default.
• W2056541759 cites W2151721316 @default.
• W2056541759 cites W2159457615 @default.
• W2056541759 cites W2161630867 @default.
• W2056541759 cites W2171723215 @default.
• W2056541759 cites W2171831801 @default.
• W2056541759 cites W4246878015 @default.
• W2056541759 doi "https://doi.org/10.2478/v10039-011-0042-y" @default.
• W2056541759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22037176" @default.
• W2056541759 hasPublicationYear "2011" @default.
• W2056541759 type Work @default.
• W2056541759 sameAs 2056541759 @default.
• W2056541759 citedByCount "22" @default.
• W2056541759 countsByYear W20565417592012 @default.
• W2056541759 countsByYear W20565417592013 @default.
• W2056541759 countsByYear W20565417592014 @default.
• W2056541759 countsByYear W20565417592015 @default.
• W2056541759 countsByYear W20565417592016 @default.
• W2056541759 countsByYear W20565417592017 @default.
• W2056541759 countsByYear W20565417592018 @default.
• W2056541759 countsByYear W20565417592020 @default.
• W2056541759 countsByYear W20565417592022 @default.
• W2056541759 countsByYear W20565417592023 @default.
• W2056541759 crossrefType "journal-article" @default.
• W2056541759 hasAuthorship W2056541759A5025273851 @default.
• W2056541759 hasAuthorship W2056541759A5027220663 @default.
• W2056541759 hasAuthorship W2056541759A5028868027 @default.
• W2056541759 hasAuthorship W2056541759A5032249239 @default.
• W2056541759 hasAuthorship W2056541759A5044757881 @default.
• W2056541759 hasAuthorship W2056541759A5074569952 @default.
• W2056541759 hasAuthorship W2056541759A5088596691 @default.
• W2056541759 hasConcept C104317684 @default.
• W2056541759 hasConcept C118552586 @default.
• W2056541759 hasConcept C119857082 @default.
• W2056541759 hasConcept C126838900 @default.
• W2056541759 hasConcept C135763542 @default.
• W2056541759 hasConcept C139275648 @default.
• W2056541759 hasConcept C143409427 @default.
• W2056541759 hasConcept C153209595 @default.
• W2056541759 hasConcept C154945302 @default.
• W2056541759 hasConcept C205778803 @default.
• W2056541759 hasConcept C2778228783 @default.
• W2056541759 hasConcept C2778538070 @default.
• W2056541759 hasConcept C2779388368 @default.
• W2056541759 hasConcept C41008148 @default.
• W2056541759 hasConcept C54355233 @default.
• W2056541759 hasConcept C71924100 @default.
• W2056541759 hasConcept C84525736 @default.
• W2056541759 hasConcept C86803240 @default.
• W2056541759 hasConceptScore W2056541759C104317684 @default.
• W2056541759 hasConceptScore W2056541759C118552586 @default.
• W2056541759 hasConceptScore W2056541759C119857082 @default.
• W2056541759 hasConceptScore W2056541759C126838900 @default.

• next