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- W2056542085 abstract "Subjects with mild cognitive impairment (MCI) are at increased risk of developing dementia. Hence, it is important to examine protective factors against cognitive decline. We investigated whether physical activity is associated with the risk of incident dementia among a cohort of subjects with prevalent MCI. We conducted a prospective cohort study derived from the population-based Mayo Clinic Study of Aging. The study sample consisted of 280 participants with prevalent MCI who underwent at least one follow-up visit. The diagnoses of MCI and dementia were made by an expert consensus panel after reviewing neurological, cognitive, and other pertinent data. The frequency and intensity (light, moderate, or vigorous) of physical exercise was estimated by using a self-reported questionnaire with ordinal response. We examined the relationship between physical exercise and incident dementia using Cox proportional hazards models with age as the time scale. The models were also adjusted for sex, education, and depression (assessed by the Beck Depression Inventory-II) to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). We prospectively followed 280 subjects with MCI for a median (inter-quartile range [IQR]) of 3.0 (2.5, 5.3) years to incident dementia or censoring variables. 58.9% were males. The median (IQR) of age was 81 [76, 85] years, and education was 12 [12, 15] years. Moderate midlife physical exercise (HR = 0.64; 95% CI 0.41-0.98) was associated with a decreased risk of incident dementia. However, neither midlife light (HR = 0.59; 95% CI, 0.33-1.04) nor midlife vigorous (HR = 0.62; 95% CI, 0.38-1.02) physical activities were significant predictors of incident dementia. Similarly, physical activity within the past year, be it light (HR = 0.89; 95% CI, 0.54-1.46), moderate (HR = 0.93; 95% CI, 0.60-1.43), or vigorous (HR = 1.34; 95% CI, 0.71-2.51), were not associated with incident dementia. Among subjects with prevalent MCI, midlife moderate physical exercise was associated with a decreased risk of incident dementia." @default.
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- W2056542085 date "2014-07-01" @default.
- W2056542085 modified "2023-09-26" @default.
- W2056542085 title "P2-153: PHYSICAL EXERCISE AND THE OUTCOME OF INCIDENT DEMENTIA: THE MAYO CLINIC STUDY OF AGING" @default.
- W2056542085 doi "https://doi.org/10.1016/j.jalz.2014.05.829" @default.
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