FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056544251> ?p ?o ?g. }

• W2056544251 abstract "We have used antigen-specific human T-cell clones to study the relationship between MHC and antigen recognition specificities expressed by T cells. Tetanus toxoid (TT)-specific T-lymphocyte clones were derived from a immunized HLA-DR2,7 heterozygous donor by limiting dilution from peripheral blood mononuclear cells (PBM) restimulated with TT in vitro. Clones were screened for MHC-restricted antigen recognition against antigen-presenting cells (APC) from a panel of HLA-typed donors, using an in vitro T-cell proliferation assay. Several distinct patterns of antigen recognition were identified. In addition to T cells that recognized TT in association with donor class II MHC antigens, we found clones that simultaneously expressed self-restricted antigen recognition and alloreactivity, and clones with specificity for antigen in the context of MHC antigens not expressed by the T-cell donor. This was confirmed in inhibition studies using well-characterized monoclonal antibodies against class II MHC antigens to block specific proliferative responses. We propose a possible structure for the determinant recognized by two of the clones. These results suggest that the T-cell antigen receptor undergoes random or antigen-dependent changes in vitro, and that this may be a mechanism for somatic diversification of the T-cell repertoire." @default.
• W2056544251 created "2016-06-24" @default.
• W2056544251 creator A5021734577 @default.
• W2056544251 creator A5023960478 @default.
• W2056544251 creator A5073805731 @default.
• W2056544251 creator A5078761568 @default.
• W2056544251 creator A5083610087 @default.
• W2056544251 date "1987-05-01" @default.
• W2056544251 modified "2023-09-25" @default.
• W2056544251 title "Major histocompatibility complex (MHC) restricted antigen recognition: High frequency of human T-cell clones recognizing novel MHC class II determinants" @default.
• W2056544251 cites W1526213826 @default.
• W2056544251 cites W1560071173 @default.
• W2056544251 cites W1573234578 @default.
• W2056544251 cites W1792446084 @default.
• W2056544251 cites W1895446510 @default.
• W2056544251 cites W1945472483 @default.
• W2056544251 cites W1965222755 @default.
• W2056544251 cites W1965917473 @default.
• W2056544251 cites W1966300007 @default.
• W2056544251 cites W1979239586 @default.
• W2056544251 cites W1981421746 @default.
• W2056544251 cites W1988997833 @default.
• W2056544251 cites W1995508824 @default.
• W2056544251 cites W1997763307 @default.
• W2056544251 cites W2006194820 @default.
• W2056544251 cites W2006724000 @default.
• W2056544251 cites W2010867882 @default.
• W2056544251 cites W2011827552 @default.
• W2056544251 cites W2017318545 @default.
• W2056544251 cites W2026108503 @default.
• W2056544251 cites W2038029623 @default.
• W2056544251 cites W2039905044 @default.
• W2056544251 cites W2044951495 @default.
• W2056544251 cites W2052636940 @default.
• W2056544251 cites W2053307347 @default.
• W2056544251 cites W2056338583 @default.
• W2056544251 cites W2065786196 @default.
• W2056544251 cites W2070098647 @default.
• W2056544251 cites W2072541124 @default.
• W2056544251 cites W2082520164 @default.
• W2056544251 cites W2082541413 @default.
• W2056544251 cites W2083774077 @default.
• W2056544251 cites W2087027341 @default.
• W2056544251 cites W2098581830 @default.
• W2056544251 cites W2108830536 @default.
• W2056544251 cites W2120370266 @default.
• W2056544251 cites W2146805638 @default.
• W2056544251 cites W2151053360 @default.
• W2056544251 cites W2157032876 @default.
• W2056544251 cites W2161303430 @default.
• W2056544251 cites W2482943223 @default.
• W2056544251 cites W2489079460 @default.
• W2056544251 cites W2494326915 @default.
• W2056544251 doi "https://doi.org/10.1016/0198-8859(87)90037-1" @default.
• W2056544251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2438261" @default.
• W2056544251 hasPublicationYear "1987" @default.
• W2056544251 type Work @default.
• W2056544251 sameAs 2056544251 @default.
• W2056544251 citedByCount "3" @default.
• W2056544251 crossrefType "journal-article" @default.
• W2056544251 hasAuthorship W2056544251A5021734577 @default.
• W2056544251 hasAuthorship W2056544251A5023960478 @default.
• W2056544251 hasAuthorship W2056544251A5073805731 @default.
• W2056544251 hasAuthorship W2056544251A5078761568 @default.
• W2056544251 hasAuthorship W2056544251A5083610087 @default.
• W2056544251 hasConcept C147483822 @default.
• W2056544251 hasConcept C153911025 @default.
• W2056544251 hasConcept C153968139 @default.
• W2056544251 hasConcept C154317977 @default.
• W2056544251 hasConcept C159654299 @default.
• W2056544251 hasConcept C170627219 @default.
• W2056544251 hasConcept C188280979 @default.
• W2056544251 hasConcept C197695756 @default.
• W2056544251 hasConcept C202751555 @default.
• W2056544251 hasConcept C203014093 @default.
• W2056544251 hasConcept C207936829 @default.
• W2056544251 hasConcept C2776090121 @default.
• W2056544251 hasConcept C542903549 @default.
• W2056544251 hasConcept C54355233 @default.
• W2056544251 hasConcept C67662055 @default.
• W2056544251 hasConcept C86803240 @default.
• W2056544251 hasConcept C8891405 @default.
• W2056544251 hasConceptScore W2056544251C147483822 @default.
• W2056544251 hasConceptScore W2056544251C153911025 @default.
• W2056544251 hasConceptScore W2056544251C153968139 @default.
• W2056544251 hasConceptScore W2056544251C154317977 @default.
• W2056544251 hasConceptScore W2056544251C159654299 @default.
• W2056544251 hasConceptScore W2056544251C170627219 @default.
• W2056544251 hasConceptScore W2056544251C188280979 @default.
• W2056544251 hasConceptScore W2056544251C197695756 @default.
• W2056544251 hasConceptScore W2056544251C202751555 @default.
• W2056544251 hasConceptScore W2056544251C203014093 @default.
• W2056544251 hasConceptScore W2056544251C207936829 @default.
• W2056544251 hasConceptScore W2056544251C2776090121 @default.
• W2056544251 hasConceptScore W2056544251C542903549 @default.
• W2056544251 hasConceptScore W2056544251C54355233 @default.
• W2056544251 hasConceptScore W2056544251C67662055 @default.
• W2056544251 hasConceptScore W2056544251C86803240 @default.
• W2056544251 hasConceptScore W2056544251C8891405 @default.
• W2056544251 hasLocation W20565442511 @default.

• next