FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056544336> ?p ?o ?g. }

• W2056544336 endingPage "1530" @default.
• W2056544336 startingPage "1524" @default.
• W2056544336 abstract "1. Currents through heteromeric P2X(2/3) receptors were evoked by applying alpha,beta-methylene-ATP to human embryonic kidney cells transfected with cDNAs encoding the P2X(2) and P2X(3) subunits. The concentration of alpha,beta-methylene-ATP were < or =30 microM because higher concentrations can activate homomeric P2X(2) receptors. The kinetics of action of three structurally unrelated antagonists were studied; these were 2', 3'-O-(2,4,6,trinitrophenyl)-ATP (TNP-ATP), pyridoxal-5-phosphate-6-azophenyl-2',4'-disulphonate (PPADS) and suramin. The association and dissociation rate constants were determined by pre-applying the antagonist for various periods prior to the co-application of agonist and antagonist, or by changing the solution from one containing only the agonist to one containing both agonist and antagonist. The high affinity of TNP-ATP for the P2X(2/3) receptor (K(D) approximately 2 nM) results from fast binding (k(+1) approximately 100 microM(-1) s(-1)) rather than slow unbinding (k(-1) approximately 0.3 s(-1)). For suramin (K(D) approximately 1 microM) the association rate constant ( approximately 1 microM(-1) s(-1)) was 100 times slower than that of TNP-ATP but the dissociation rate constant was similar (k(-1) approximately 1 s(-1)). PPADS (K(D) approximately 0.1 microM) associated and dissociated some 100 - 10,000 times more slowly than the other antagonists." @default.
• W2056544336 created "2016-06-24" @default.
• W2056544336 creator A5045949797 @default.
• W2056544336 creator A5046853189 @default.
• W2056544336 creator A5084712627 @default.
• W2056544336 creator A5088196965 @default.
• W2056544336 date "2002-03-01" @default.
• W2056544336 modified "2023-09-26" @default.
• W2056544336 title "Kinetics of antagonist actions at rat P2X_2/3 heteromeric receptors" @default.
• W2056544336 cites W1503666079 @default.
• W2056544336 cites W1554203003 @default.
• W2056544336 cites W1623121663 @default.
• W2056544336 cites W1709464822 @default.
• W2056544336 cites W1837514060 @default.
• W2056544336 cites W1862246641 @default.
• W2056544336 cites W1896587953 @default.
• W2056544336 cites W1932042474 @default.
• W2056544336 cites W1979882055 @default.
• W2056544336 cites W2014659837 @default.
• W2056544336 cites W2016528015 @default.
• W2056544336 cites W2019857469 @default.
• W2056544336 cites W2031039258 @default.
• W2056544336 cites W2035838035 @default.
• W2056544336 cites W2039689709 @default.
• W2056544336 cites W2040331213 @default.
• W2056544336 cites W2048201868 @default.
• W2056544336 cites W2056882527 @default.
• W2056544336 cites W2057551724 @default.
• W2056544336 cites W2069913132 @default.
• W2056544336 cites W2093099040 @default.
• W2056544336 cites W2094898956 @default.
• W2056544336 cites W2106912151 @default.
• W2056544336 cites W2113565576 @default.
• W2056544336 cites W2133951476 @default.
• W2056544336 cites W2136134177 @default.
• W2056544336 cites W2139506271 @default.
• W2056544336 cites W2140327830 @default.
• W2056544336 cites W2155705076 @default.
• W2056544336 cites W2186566705 @default.
• W2056544336 cites W2259281963 @default.
• W2056544336 cites W2280241881 @default.
• W2056544336 doi "https://doi.org/10.1038/sj.bjp.0704591" @default.
• W2056544336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1573256" @default.
• W2056544336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11906966" @default.
• W2056544336 hasPublicationYear "2002" @default.
• W2056544336 type Work @default.
• W2056544336 sameAs 2056544336 @default.
• W2056544336 citedByCount "51" @default.
• W2056544336 countsByYear W20565443362012 @default.
• W2056544336 countsByYear W20565443362013 @default.
• W2056544336 countsByYear W20565443362014 @default.
• W2056544336 countsByYear W20565443362015 @default.
• W2056544336 countsByYear W20565443362019 @default.
• W2056544336 countsByYear W20565443362022 @default.
• W2056544336 countsByYear W20565443362023 @default.
• W2056544336 crossrefType "journal-article" @default.
• W2056544336 hasAuthorship W2056544336A5045949797 @default.
• W2056544336 hasAuthorship W2056544336A5046853189 @default.
• W2056544336 hasAuthorship W2056544336A5084712627 @default.
• W2056544336 hasAuthorship W2056544336A5088196965 @default.
• W2056544336 hasBestOaLocation W20565443362 @default.
• W2056544336 hasConcept C104292427 @default.
• W2056544336 hasConcept C104317684 @default.
• W2056544336 hasConcept C12554922 @default.
• W2056544336 hasConcept C170493617 @default.
• W2056544336 hasConcept C185592680 @default.
• W2056544336 hasConcept C2776104367 @default.
• W2056544336 hasConcept C2776182878 @default.
• W2056544336 hasConcept C2776885963 @default.
• W2056544336 hasConcept C2778938600 @default.
• W2056544336 hasConcept C2780019924 @default.
• W2056544336 hasConcept C2780410667 @default.
• W2056544336 hasConcept C55493867 @default.
• W2056544336 hasConcept C71240020 @default.
• W2056544336 hasConcept C74998103 @default.
• W2056544336 hasConcept C86803240 @default.
• W2056544336 hasConcept C86811712 @default.
• W2056544336 hasConceptScore W2056544336C104292427 @default.
• W2056544336 hasConceptScore W2056544336C104317684 @default.
• W2056544336 hasConceptScore W2056544336C12554922 @default.
• W2056544336 hasConceptScore W2056544336C170493617 @default.
• W2056544336 hasConceptScore W2056544336C185592680 @default.
• W2056544336 hasConceptScore W2056544336C2776104367 @default.
• W2056544336 hasConceptScore W2056544336C2776182878 @default.
• W2056544336 hasConceptScore W2056544336C2776885963 @default.
• W2056544336 hasConceptScore W2056544336C2778938600 @default.
• W2056544336 hasConceptScore W2056544336C2780019924 @default.
• W2056544336 hasConceptScore W2056544336C2780410667 @default.
• W2056544336 hasConceptScore W2056544336C55493867 @default.
• W2056544336 hasConceptScore W2056544336C71240020 @default.
• W2056544336 hasConceptScore W2056544336C74998103 @default.
• W2056544336 hasConceptScore W2056544336C86803240 @default.
• W2056544336 hasConceptScore W2056544336C86811712 @default.
• W2056544336 hasIssue "6" @default.
• W2056544336 hasLocation W20565443361 @default.
• W2056544336 hasLocation W20565443362 @default.
• W2056544336 hasLocation W20565443363 @default.
• W2056544336 hasLocation W20565443364 @default.

• next