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- W2056544743 startingPage "2979" @default.
- W2056544743 abstract "The binding affinities of racemic derivatives of propranolol to β-adrenoceptors were examined by means of radioligand binding assay to determine whether racemic propranolol shows biphasic binding to β-adrenoceptors in a displacement experiment. Rat brain was used and the β-adrenoceptor binding assay was carried out with 3H-dihydroalprenolol as the radioligand. A higher affinity of l-propranolol than of d-propranolol was observed and d-and l-propranolol each gave a uniphasic curve. However, dl-propranolol showed a biphasic curve. Furthermore, a mixture of d-and l-propranolol also showed a biphasic curve. These results imply that β-adrenoceptors of rat brain may bind the d-and l-isomers at distinct sites." @default.
- W2056544743 created "2016-06-24" @default.
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- W2056544743 date "1987-01-01" @default.
- W2056544743 modified "2023-09-25" @default.
- W2056544743 title "Characterization of 3H-dihydroalprenolol binding to .BETA.-adrenergic receptors of rat brain: Two binding sites of racemic propranolol in displacement experiments." @default.
- W2056544743 cites W2146907325 @default.
- W2056544743 doi "https://doi.org/10.1248/cpb.35.2979" @default.
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