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• W2056544949 abstract "Background Patients taking antiplatelet agents (APAs) with intracranial hemorrhage (ICH) may be treated with platelet transfusion. Objectives We conducted a systematic review of the use of platelet transfusion in the management of APA-related ICH. Methods We searched the Cochrane, Medline, Embase, and CINAHL databases. Included studies were randomized, case-controlled, or cohort studies comparing outcomes in adult patients with APA-related ICH who received or did not receive platelet transfusion. Study quality was measured using appropriate scores. The primary outcome of interest was in-hospital mortality rate. Secondary outcomes included rates of craniotomy, neurological, medical, or radiological deterioration; mean length of hospital stay, delayed mortality, and functional status at discharge. We reported proportions, medians with interquartile ranges, and pooled odds ratios with their 95% confidence intervals. p values < 0.05 were considered statistically significant. Results There were no randomized controlled trials. Seven retrospective cohort studies (four traumatic, three primary ICH) were included. For APA-related traumatic ICH, the pooled odds ratio (OR) for in-hospital mortality with platelet transfusion was 1.77 (95% confidence interval [CI] 1.00–3.13). There were no statistically significant differences for secondary outcomes except for proportion with medical decline (6/44 vs. 2/64; p = 0.006). For APA-related primary ICH, the pooled OR for in-hospital mortality with platelet transfusion was 0.49 (95% CI 0.24–0.98). There were no statistically significant differences for most secondary outcomes between the two groups. These studies had important methodological limitations. Conclusions The evidence for platelet transfusion in APA-related ICH was inconclusive due to methodological limitations." @default.
• W2056544949 created "2016-06-24" @default.
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• W2056544949 date "2015-10-01" @default.
• W2056544949 modified "2023-09-27" @default.
• W2056544949 title "Is Platelet Transfusion Effective in Patients Taking Antiplatelet Agents Who Suffer an Intracranial Hemorrhage?" @default.
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• W2056544949 doi "https://doi.org/10.1016/j.jemermed.2015.02.023" @default.
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