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• W2056547882 startingPage "867" @default.
• W2056547882 abstract "Abstract Langerhans cell histiocytosis (LCH) is a rare disease affecting people of any age, with widely variable clinical manifestations and different outcomes. The precise chain of events driving lesional granuloma formation has remained elusive for many years. There is evidence for inherited predisposition to and derangement of apoptosis and inflammation in lesional dendritic cells. Recently somatic BRAFV600E mutation in myeloid precursor dendritic cells was associated with the more aggressive form of the disease, although the same mutation in a more differentiated dendritic cell might drive a less aggressive disease. Whether this picture convincingly put LCH in the field of myeloid neoplasm remains to be determined. Altogether, these findings suggest that future therapeutic strategy might incorporate a screening of this genetic mutation for high-risk patients potentially suitable for target therapy." @default.
• W2056547882 created "2016-06-24" @default.
• W2056547882 creator A5040048031 @default.
• W2056547882 creator A5070232314 @default.
• W2056547882 date "2014-08-07" @default.
• W2056547882 modified "2023-10-16" @default.
• W2056547882 title "Blood spotlight on Langerhans cell histiocytosis" @default.
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• W2056547882 doi "https://doi.org/10.1182/blood-2014-02-556407" @default.
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