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- W2056547995 abstract "Endothelial cell dysfunction is considered to be a major cause of vascular complications in diabetes. In the present study, we investigated the protective effect of a baechu kimchi added Ecklonia cava extract (BKE) against high glucose induced oxidative damage in human umbilical vein endothelial cells (HUVECs). Treatment with a high concentration of glucose (30 mM) induced cytotoxicity, whereas treatment with BKE protected HUVECs from high glucose induced damage; by restoring cell viability. In addition, BKE reduced lipid peroxidation, intracellular reactive oxygen species and nitric oxide levels in a dose dependent manner. Treatment with high glucose concentrations also induced the overexpression of inducible nitric oxide synthase, cyclooxygenase-2 and NF-κB proteins in HUVECs, but BKE treatment significantly reduced the overexpression of these proteins. These findings indicate that BKE may be a valuable treatment against high glucose-induced oxidative stress HUVECs." @default.
- W2056547995 created "2016-06-24" @default.
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- W2056547995 date "2014-09-30" @default.
- W2056547995 modified "2023-09-26" @default.
- W2056547995 title "Effect of Baechu Kimchi Added Ecklonia cava Extracts on High Glucose-induced Oxidative Stress in Human Umbilical Vein Endothelial Cells" @default.
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- W2056547995 doi "https://doi.org/10.3746/pnf.2014.19.3.170" @default.
- W2056547995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4195622" @default.
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