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- W2056548494 abstract "A method of a priori prediction of whether complex formation will lead to enhancement or reduction of the transport rate of a drug across biological membranes is presented. It is shown that compounding a drug with substances of lower diffusion coefficients, with which the drug will form a complex, leads to enhancement of the flux of the drug; compounding with substances with similar diffusion coefficients results in a reduction of the transport rate of unassociated drug (flux), provided the rate constants for association‐dissociation reactions are of similar magnitude. Detailed methods of computation of fluxes and concentration profiles are included." @default.
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- W2056548494 date "1972-06-01" @default.
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- W2056548494 title "Influence of Complex Formation on Drug Transport" @default.
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- W2056548494 doi "https://doi.org/10.1002/jps.2600610613" @default.
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