Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056549191> ?p ?o ?g. }
- W2056549191 endingPage "1719" @default.
- W2056549191 startingPage "1713" @default.
- W2056549191 abstract "S100 proteins bind to numerous target proteins, as well as other S100 proteins and activate signaling cascades. S100 proteins can be modified by various post-translational modifications, such as phosphorylation, methylation and acetylation. In addition, oxidation is important for modulating their activities. Previous studies have shown that S100A1 interacts with S100A4 in vitro and in vivo. Due to this potential cross‑talk among the S100 proteins, the aim of the present study was to examine whether S100A4 modulates the activity of S100A1. S100A4 was readily oxidized and formed disulfide-linked dimers and oligomers. Although non-oxidized S100A4 bound to protein phosphatase 5 (PP5), the Cu-oxidized S100A4 failed to bind PP5. Instead, the Cu-oxidized S100A4 directly interacted with S100A1 and prevented PP5 activation. Hydrogen peroxide induced S100A4 oxidation in MKN-45 gastric adenocarcinoma cells and decreased S100A1‑PP5 interaction, resulted in the inhibition of PP5 activation by S100A1. These data indicate that oxidized S100A4 regulates PP5 activity in a unique manner under oxidative stress conditions." @default.
- W2056549191 created "2016-06-24" @default.
- W2056549191 creator A5028305352 @default.
- W2056549191 creator A5042908365 @default.
- W2056549191 creator A5050262032 @default.
- W2056549191 creator A5072880634 @default.
- W2056549191 creator A5076383419 @default.
- W2056549191 creator A5078658497 @default.
- W2056549191 creator A5091409148 @default.
- W2056549191 date "2014-09-29" @default.
- W2056549191 modified "2023-10-14" @default.
- W2056549191 title "Oxidized S100A4 inhibits the activation of protein phosphatase 5 through S100A1 in MKN-45 gastric carcinoma cells" @default.
- W2056549191 cites W1491031366 @default.
- W2056549191 cites W1537094542 @default.
- W2056549191 cites W1628979938 @default.
- W2056549191 cites W1633015885 @default.
- W2056549191 cites W1968507864 @default.
- W2056549191 cites W1970413355 @default.
- W2056549191 cites W1977154467 @default.
- W2056549191 cites W1983256420 @default.
- W2056549191 cites W1988572399 @default.
- W2056549191 cites W1991648097 @default.
- W2056549191 cites W1998571837 @default.
- W2056549191 cites W1999249821 @default.
- W2056549191 cites W2019128605 @default.
- W2056549191 cites W2026012418 @default.
- W2056549191 cites W2027548893 @default.
- W2056549191 cites W2032150619 @default.
- W2056549191 cites W2035666161 @default.
- W2056549191 cites W2037564173 @default.
- W2056549191 cites W2039663629 @default.
- W2056549191 cites W2049631853 @default.
- W2056549191 cites W2054091018 @default.
- W2056549191 cites W2059595437 @default.
- W2056549191 cites W2063483894 @default.
- W2056549191 cites W2070024066 @default.
- W2056549191 cites W2074759579 @default.
- W2056549191 cites W2078899029 @default.
- W2056549191 cites W2079290629 @default.
- W2056549191 cites W2095663905 @default.
- W2056549191 cites W2101430080 @default.
- W2056549191 cites W2123404680 @default.
- W2056549191 cites W2136055108 @default.
- W2056549191 cites W2140847300 @default.
- W2056549191 cites W2141439542 @default.
- W2056549191 cites W2152357501 @default.
- W2056549191 cites W2161189488 @default.
- W2056549191 cites W2412365627 @default.
- W2056549191 cites W2418927955 @default.
- W2056549191 cites W4248451563 @default.
- W2056549191 cites W4362060338 @default.
- W2056549191 doi "https://doi.org/10.3892/ijmm.2014.1947" @default.
- W2056549191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25269953" @default.
- W2056549191 hasPublicationYear "2014" @default.
- W2056549191 type Work @default.
- W2056549191 sameAs 2056549191 @default.
- W2056549191 citedByCount "8" @default.
- W2056549191 countsByYear W20565491912017 @default.
- W2056549191 countsByYear W20565491912018 @default.
- W2056549191 countsByYear W20565491912021 @default.
- W2056549191 crossrefType "journal-article" @default.
- W2056549191 hasAuthorship W2056549191A5028305352 @default.
- W2056549191 hasAuthorship W2056549191A5042908365 @default.
- W2056549191 hasAuthorship W2056549191A5050262032 @default.
- W2056549191 hasAuthorship W2056549191A5072880634 @default.
- W2056549191 hasAuthorship W2056549191A5076383419 @default.
- W2056549191 hasAuthorship W2056549191A5078658497 @default.
- W2056549191 hasAuthorship W2056549191A5091409148 @default.
- W2056549191 hasBestOaLocation W20565491911 @default.
- W2056549191 hasConcept C104317684 @default.
- W2056549191 hasConcept C119157956 @default.
- W2056549191 hasConcept C11960822 @default.
- W2056549191 hasConcept C178666793 @default.
- W2056549191 hasConcept C185592680 @default.
- W2056549191 hasConcept C2780429522 @default.
- W2056549191 hasConcept C55493867 @default.
- W2056549191 hasConcept C86803240 @default.
- W2056549191 hasConcept C95444343 @default.
- W2056549191 hasConceptScore W2056549191C104317684 @default.
- W2056549191 hasConceptScore W2056549191C119157956 @default.
- W2056549191 hasConceptScore W2056549191C11960822 @default.
- W2056549191 hasConceptScore W2056549191C178666793 @default.
- W2056549191 hasConceptScore W2056549191C185592680 @default.
- W2056549191 hasConceptScore W2056549191C2780429522 @default.
- W2056549191 hasConceptScore W2056549191C55493867 @default.
- W2056549191 hasConceptScore W2056549191C86803240 @default.
- W2056549191 hasConceptScore W2056549191C95444343 @default.
- W2056549191 hasIssue "6" @default.
- W2056549191 hasLocation W20565491911 @default.
- W2056549191 hasLocation W20565491912 @default.
- W2056549191 hasOpenAccess W2056549191 @default.
- W2056549191 hasPrimaryLocation W20565491911 @default.
- W2056549191 hasRelatedWork W1477071538 @default.
- W2056549191 hasRelatedWork W1920840680 @default.
- W2056549191 hasRelatedWork W1966256275 @default.
- W2056549191 hasRelatedWork W2003542666 @default.
- W2056549191 hasRelatedWork W2033643414 @default.
- W2056549191 hasRelatedWork W2081246372 @default.