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- W2056549224 abstract "Purpose of review The purpose of the current article is to review the most recent information on the role of viral quasispecies on the recurrence of hepatitis C in liver transplantation patients. Recent findings Data from several recent studies suggest that hepatitis C virus (HCV) genetic diversity, especially of the hypervariable region 1, can influence the course of HCV recurrence after liver transplantation. Patients with severe HCV recurrence, as defined by advanced fibrosis on follow-up biopsy, generally show greater viral genetic homogeneity—that is, less diversity in viral quasispecies—compared with patients with less advanced liver fibrosis. The reduced diversity is thought to reflect a greater state of immunosuppression and hence less pressure acting on the virus to change its genetic make-up, especially the hypervariable region 1, which is the target for potentially neutralizing antibodies. Summary Quasispecies analyses by different investigators have conflicted with regard to the importance of quasispecies in HCV recurrence after liver transplantation. This is in part because of small sample size, nonuniform time points, differing analysis techniques, and differing definitions of genetic diversity. Because of the great potential for diagnostic and therapeutic use, future study of quasispecies diversity and complexity should be conducted in larger trials with well-defined histologic and clinical outcomes, and protocol-defined liver biopsies and controlled immunosuppressive regimens. This approach will allow better definition of the role of viral quasispecies in the pathogenesis and severity of recurrence of posttransplant hepatitis C infection." @default.
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- W2056549224 date "2004-06-01" @default.
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- W2056549224 title "Recurrent hepatitis C virus after liver transplantation" @default.
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- W2056549224 doi "https://doi.org/10.1097/01.mot.0000127679.62641.52" @default.
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