Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056549760> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2056549760 endingPage "708" @default.
- W2056549760 startingPage "703" @default.
- W2056549760 abstract "In January 1988, we initiated a prospective study evaluating a new treatment approach with chemotherapy and radiotherapy for unresectable head and neck cancer. Weeks 1–4 were the initial debulking phase. Radiotherapy was delivered using 1.8 Gy/day to large portals including gross disease and all areas at risk. Cisplatinum, 100mg/m2 was given concomitant with radiotherapy on days 1 and 22. Weeks 5 and 6 were the boosting phase. This involved twice-a-day irradiation. The AM fraction of 1.8 Gy was given to the entire area at risk, whereas the PM dose of 1.6 Gy was limited to the gross disease alone. Thus a total of 70 Gy/6 weeks was delivered. A total of 24 patients were treated, 22 of whom have completed this protocol and are evaluable. All patients had massive disease, with 15 having gross involvement of brain, orbit, skull base, or carotid artery. Follow-up ranged from 3–22 months (median 12 months). Major responses were achieved in 96%, with 64% complete responses and 32% partial responses. Two patients with PR were able to undergo complete surgical resection, making the overall rate of complete response, including surgery, 73%. At 1 year, actuarial survival was 69%, and local progression-free survival was 56%. Distant metastases developed in 5 (23%). This approach appears both safe and effective in producing excellent regression and local control for far advanced head and neck cancer. More time is needed to see if these results are sustained. Efforts to build upon this experience appear warranted." @default.
- W2056549760 created "2016-06-24" @default.
- W2056549760 creator A5005775817 @default.
- W2056549760 creator A5009871905 @default.
- W2056549760 creator A5011915135 @default.
- W2056549760 creator A5016949209 @default.
- W2056549760 creator A5029086251 @default.
- W2056549760 creator A5031748760 @default.
- W2056549760 creator A5046046756 @default.
- W2056549760 creator A5051730744 @default.
- W2056549760 creator A5062419531 @default.
- W2056549760 creator A5080353949 @default.
- W2056549760 date "1991-08-01" @default.
- W2056549760 modified "2023-10-15" @default.
- W2056549760 title "Concomitant chemotherapy-radiation therapy followed by hyperfractionated radiation therapy for advanced unresectable head and neck cancer" @default.
- W2056549760 cites W1943977034 @default.
- W2056549760 cites W1982238941 @default.
- W2056549760 cites W2000754251 @default.
- W2056549760 cites W2010906774 @default.
- W2056549760 cites W2016681837 @default.
- W2056549760 cites W2055154319 @default.
- W2056549760 cites W2065266240 @default.
- W2056549760 cites W2069568200 @default.
- W2056549760 cites W2074477840 @default.
- W2056549760 cites W2082863696 @default.
- W2056549760 cites W2083720245 @default.
- W2056549760 cites W2103094946 @default.
- W2056549760 cites W2138477625 @default.
- W2056549760 cites W2180275997 @default.
- W2056549760 cites W3041047318 @default.
- W2056549760 doi "https://doi.org/10.1016/0360-3016(91)90689-2" @default.
- W2056549760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1869464" @default.
- W2056549760 hasPublicationYear "1991" @default.
- W2056549760 type Work @default.
- W2056549760 sameAs 2056549760 @default.
- W2056549760 citedByCount "51" @default.
- W2056549760 countsByYear W20565497602012 @default.
- W2056549760 countsByYear W20565497602013 @default.
- W2056549760 countsByYear W20565497602016 @default.
- W2056549760 countsByYear W20565497602022 @default.
- W2056549760 crossrefType "journal-article" @default.
- W2056549760 hasAuthorship W2056549760A5005775817 @default.
- W2056549760 hasAuthorship W2056549760A5009871905 @default.
- W2056549760 hasAuthorship W2056549760A5011915135 @default.
- W2056549760 hasAuthorship W2056549760A5016949209 @default.
- W2056549760 hasAuthorship W2056549760A5029086251 @default.
- W2056549760 hasAuthorship W2056549760A5031748760 @default.
- W2056549760 hasAuthorship W2056549760A5046046756 @default.
- W2056549760 hasAuthorship W2056549760A5051730744 @default.
- W2056549760 hasAuthorship W2056549760A5062419531 @default.
- W2056549760 hasAuthorship W2056549760A5080353949 @default.
- W2056549760 hasConcept C121608353 @default.
- W2056549760 hasConcept C126322002 @default.
- W2056549760 hasConcept C141071460 @default.
- W2056549760 hasConcept C2776530083 @default.
- W2056549760 hasConcept C2779384505 @default.
- W2056549760 hasConcept C2780427987 @default.
- W2056549760 hasConcept C2781100745 @default.
- W2056549760 hasConcept C509974204 @default.
- W2056549760 hasConcept C71924100 @default.
- W2056549760 hasConceptScore W2056549760C121608353 @default.
- W2056549760 hasConceptScore W2056549760C126322002 @default.
- W2056549760 hasConceptScore W2056549760C141071460 @default.
- W2056549760 hasConceptScore W2056549760C2776530083 @default.
- W2056549760 hasConceptScore W2056549760C2779384505 @default.
- W2056549760 hasConceptScore W2056549760C2780427987 @default.
- W2056549760 hasConceptScore W2056549760C2781100745 @default.
- W2056549760 hasConceptScore W2056549760C509974204 @default.
- W2056549760 hasConceptScore W2056549760C71924100 @default.
- W2056549760 hasIssue "3" @default.
- W2056549760 hasLocation W20565497601 @default.
- W2056549760 hasLocation W20565497602 @default.
- W2056549760 hasOpenAccess W2056549760 @default.
- W2056549760 hasPrimaryLocation W20565497601 @default.
- W2056549760 hasRelatedWork W162261237 @default.
- W2056549760 hasRelatedWork W2067177021 @default.
- W2056549760 hasRelatedWork W2070829392 @default.
- W2056549760 hasRelatedWork W2147863910 @default.
- W2056549760 hasRelatedWork W2154830016 @default.
- W2056549760 hasRelatedWork W2508892041 @default.
- W2056549760 hasRelatedWork W2949747618 @default.
- W2056549760 hasRelatedWork W2949811493 @default.
- W2056549760 hasRelatedWork W2950006216 @default.
- W2056549760 hasRelatedWork W4319660618 @default.
- W2056549760 hasVolume "21" @default.
- W2056549760 isParatext "false" @default.
- W2056549760 isRetracted "false" @default.
- W2056549760 magId "2056549760" @default.
- W2056549760 workType "article" @default.