FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056550113> ?p ?o ?g. }

• W2056550113 endingPage "173" @default.
• W2056550113 startingPage "168" @default.
• W2056550113 abstract "In this study, we examined antihyperalgesic and analgesic actions after local peripheral administration of ketamine and amitriptyline in a rat model of mild thermal injury. Exposure of the hindpaw to 52 degrees C for 45 s under anesthesia produced a subsequent thermal hyperalgesia lasting at least 2 h. The local peripheral administration of ketamine (100-1000 nmol) 15 min before the thermal injury produced an antihyperalgesic effect when injected into the ipsilateral paw, whereas amitriptyline produced both antihyperalgesic (300 nmol) and analgesic (1000 nmol) effects. Administered after the thermal injury, ketamine had no effect, whereas amitriptyline retained its analgesic but not its antihyperalgesic effect. Amitriptyline (300 and 1000 nmol) produced an analgesic action when administered into the normal nonsensitized hindpaw. Both drugs increase paw volume, particularly at larger doses; biogenic amines are not involved in the action of amitriptyline, as was shown previously for ketamine. These results indicate that (a) ketamine produces antihyperalgesia, but not analgesia, when administered locally with a mild thermal injury model; (b) amitriptyline produces both antihyperalgesia and analgesia when administered locally; and (c) the increase in paw volume produced by these drugs occurs by different mechanisms.This study examines the pain-relieving properties of the local peripheral administration of ketamine and amitriptyline, two drugs in current clinical use, in a thermal injury model of hyperalgesia and demonstrates both antihyperalgesic and analgesic properties. These observations provide support for their potential use as local (e.g., topical) analgesics." @default.
• W2056550113 created "2016-06-24" @default.
• W2056550113 creator A5012815771 @default.
• W2056550113 creator A5043846382 @default.
• W2056550113 creator A5081454540 @default.
• W2056550113 date "2003-07-01" @default.
• W2056550113 modified "2023-09-24" @default.
• W2056550113 title "Peripheral Antihyperalgesic and Analgesic Actions of Ketamine and Amitriptyline in a Model of Mild Thermal Injury in the Rat" @default.
• W2056550113 cites W1575571855 @default.
• W2056550113 cites W1964816489 @default.
• W2056550113 cites W1978939719 @default.
• W2056550113 cites W1978989391 @default.
• W2056550113 cites W1982292219 @default.
• W2056550113 cites W1984247805 @default.
• W2056550113 cites W1994154408 @default.
• W2056550113 cites W1995535776 @default.
• W2056550113 cites W1996012888 @default.
• W2056550113 cites W1998708773 @default.
• W2056550113 cites W2002946197 @default.
• W2056550113 cites W2011557494 @default.
• W2056550113 cites W2014007136 @default.
• W2056550113 cites W2020820202 @default.
• W2056550113 cites W2026820267 @default.
• W2056550113 cites W2027931777 @default.
• W2056550113 cites W2038865306 @default.
• W2056550113 cites W2038911477 @default.
• W2056550113 cites W2043075812 @default.
• W2056550113 cites W2047630289 @default.
• W2056550113 cites W2055513620 @default.
• W2056550113 cites W2057439534 @default.
• W2056550113 cites W2058041280 @default.
• W2056550113 cites W2061014791 @default.
• W2056550113 cites W2062390007 @default.
• W2056550113 cites W2072464207 @default.
• W2056550113 cites W2094479806 @default.
• W2056550113 cites W2102023851 @default.
• W2056550113 cites W2115339838 @default.
• W2056550113 cites W2116031458 @default.
• W2056550113 cites W2125454594 @default.
• W2056550113 cites W2158067363 @default.
• W2056550113 cites W2168663923 @default.
• W2056550113 cites W2171543760 @default.
• W2056550113 cites W27717426 @default.
• W2056550113 cites W4246062575 @default.
• W2056550113 doi "https://doi.org/10.1213/01.ane.0000067406.52093.bf" @default.
• W2056550113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12818961" @default.
• W2056550113 hasPublicationYear "2003" @default.
• W2056550113 type Work @default.
• W2056550113 sameAs 2056550113 @default.
• W2056550113 citedByCount "50" @default.
• W2056550113 countsByYear W20565501132012 @default.
• W2056550113 countsByYear W20565501132013 @default.
• W2056550113 countsByYear W20565501132014 @default.
• W2056550113 countsByYear W20565501132015 @default.
• W2056550113 countsByYear W20565501132016 @default.
• W2056550113 countsByYear W20565501132017 @default.
• W2056550113 countsByYear W20565501132019 @default.
• W2056550113 countsByYear W20565501132020 @default.
• W2056550113 crossrefType "journal-article" @default.
• W2056550113 hasAuthorship W2056550113A5012815771 @default.
• W2056550113 hasAuthorship W2056550113A5043846382 @default.
• W2056550113 hasAuthorship W2056550113A5081454540 @default.
• W2056550113 hasBestOaLocation W20565501131 @default.
• W2056550113 hasConcept C126322002 @default.
• W2056550113 hasConcept C15490471 @default.
• W2056550113 hasConcept C170493617 @default.
• W2056550113 hasConcept C2779245659 @default.
• W2056550113 hasConcept C2780216858 @default.
• W2056550113 hasConcept C2780795376 @default.
• W2056550113 hasConcept C2780820201 @default.
• W2056550113 hasConcept C2781081902 @default.
• W2056550113 hasConcept C42219234 @default.
• W2056550113 hasConcept C71924100 @default.
• W2056550113 hasConcept C98274493 @default.
• W2056550113 hasConceptScore W2056550113C126322002 @default.
• W2056550113 hasConceptScore W2056550113C15490471 @default.
• W2056550113 hasConceptScore W2056550113C170493617 @default.
• W2056550113 hasConceptScore W2056550113C2779245659 @default.
• W2056550113 hasConceptScore W2056550113C2780216858 @default.
• W2056550113 hasConceptScore W2056550113C2780795376 @default.
• W2056550113 hasConceptScore W2056550113C2780820201 @default.
• W2056550113 hasConceptScore W2056550113C2781081902 @default.
• W2056550113 hasConceptScore W2056550113C42219234 @default.
• W2056550113 hasConceptScore W2056550113C71924100 @default.
• W2056550113 hasConceptScore W2056550113C98274493 @default.
• W2056550113 hasLocation W20565501131 @default.
• W2056550113 hasLocation W20565501132 @default.
• W2056550113 hasLocation W20565501133 @default.
• W2056550113 hasOpenAccess W2056550113 @default.
• W2056550113 hasPrimaryLocation W20565501131 @default.
• W2056550113 hasRelatedWork W2014449755 @default.
• W2056550113 hasRelatedWork W2027931777 @default.
• W2056550113 hasRelatedWork W2041047580 @default.
• W2056550113 hasRelatedWork W2043072722 @default.
• W2056550113 hasRelatedWork W2043363666 @default.
• W2056550113 hasRelatedWork W2056550113 @default.
• W2056550113 hasRelatedWork W2093313087 @default.
• W2056550113 hasRelatedWork W2241520622 @default.

• next