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• W2056550498 abstract "To investigate the clinical characteristics of uterine myomas with cytogenetic rearrangements.Comparative study of myomas with normal and abnormal karyotype.University hospital.Premenopausal, GnRH-agonist (GnRH-a) treated and menopausal patients.Myomectomy or hysterectomy.Karyotype analysis and clinical characteristics.Clonal abnormalities occurred in 29% of uterine myomas but were not related to the age of the patient or, in untreated menopausal patients, to the size of the myoma. In GnRH-a treated and menopausal women, 48% of the myomas larger than 4 cm were associated with clonal abnormalities. Submucous myomas had significantly fewer clonal abnormalities (12%) than subserosal (29%) or intramural myomas (35%).The data support the hypothesis that cytogenetic rearrangements in uterine myomas are associated with loss of steroid hormones dependency and alter the growth potential of the tumor." @default.
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• W2056550498 date "1998-02-01" @default.
• W2056550498 modified "2023-10-02" @default.
• W2056550498 title "Clinical significance of cytogenetic abnormalities in uterine myomas" @default.
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• W2056550498 doi "https://doi.org/10.1016/s0015-0282(97)00472-x" @default.
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