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- W2056550647 abstract "SIR1, one of several genes required for repression of yeast silent mating type loci, has a unique role in repression of the HMLα locus. Single-cell assays revealed that cells with mutant alleles of SIR1, including presumptive null alleles, existed as populations of genetically identical cells whose members were in one of two different regulatory states. A minority of cells had a repressed HMLα locus whereas the majority had a derepressed HMLα locus. The two states were mitotically stable, although rare changes in state were observed during mitotic growth, possibly reflecting heritable changes to the HMLα locus at or before replication. Analysis of changes in state suggests that SIR1 protein has a role in the establishment but not the maintenance of repression of silent mating type genes, whereas SIR2, SIR3, and SIR4 are required for maintenance." @default.
- W2056550647 created "2016-06-24" @default.
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- W2056550647 creator A5088238437 @default.
- W2056550647 date "1989-11-01" @default.
- W2056550647 modified "2023-10-14" @default.
- W2056550647 title "Epigenetic inheritance of transcriptional states in S. cerevisiae" @default.
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- W2056550647 doi "https://doi.org/10.1016/0092-8674(89)90009-3" @default.
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