Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056551165> ?p ?o ?g. }
- W2056551165 endingPage "601" @default.
- W2056551165 startingPage "589" @default.
- W2056551165 abstract "Major depressive disorder (MDD) is a highly prevalent disorder with substantial heritability. Heritability has been shown to be substantial and higher in the variant of MDD characterized by recurrent episodes of depression. Genetic studies have thus far failed to identify clear and consistent evidence of genetic risk factors for MDD. We conducted a genome-wide association study (GWAS) in two independent datasets. The first GWAS was performed on 1022 recurrent MDD patients and 1000 controls genotyped on the Illumina 550 platform. The second was conducted on 492 recurrent MDD patients and 1052 controls selected from a population-based collection, genotyped on the Affymetrix 5.0 platform. Neither GWAS identified any SNP that achieved GWAS significance. We obtained imputed genotypes at the Illumina loci for the individuals genotyped on the Affymetrix platform, and performed a meta-analysis of the two GWASs for this common set of approximately half a million SNPs. The meta-analysis did not yield genome-wide significant results either. The results from our study suggest that SNPs with substantial odds ratio are unlikely to exist for MDD, at least in our datasets and among the relatively common SNPs genotyped or tagged by the half-million-loci arrays. Meta-analysis of larger datasets is warranted to identify SNPs with smaller effects or with rarer allele frequencies that contribute to the risk of MDD." @default.
- W2056551165 created "2016-06-24" @default.
- W2056551165 creator A5003486843 @default.
- W2056551165 creator A5006541865 @default.
- W2056551165 creator A5007814849 @default.
- W2056551165 creator A5009295406 @default.
- W2056551165 creator A5022374956 @default.
- W2056551165 creator A5026534206 @default.
- W2056551165 creator A5033168742 @default.
- W2056551165 creator A5037140624 @default.
- W2056551165 creator A5041323025 @default.
- W2056551165 creator A5044329719 @default.
- W2056551165 creator A5044356203 @default.
- W2056551165 creator A5047361673 @default.
- W2056551165 creator A5047797878 @default.
- W2056551165 creator A5050995972 @default.
- W2056551165 creator A5059178363 @default.
- W2056551165 creator A5071050491 @default.
- W2056551165 creator A5071616414 @default.
- W2056551165 creator A5079479859 @default.
- W2056551165 creator A5088866740 @default.
- W2056551165 creator A5089024916 @default.
- W2056551165 date "2008-12-23" @default.
- W2056551165 modified "2023-10-15" @default.
- W2056551165 title "Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts" @default.
- W2056551165 cites W1551600243 @default.
- W2056551165 cites W1557545815 @default.
- W2056551165 cites W1968479140 @default.
- W2056551165 cites W1971321176 @default.
- W2056551165 cites W1971816469 @default.
- W2056551165 cites W1974286604 @default.
- W2056551165 cites W1988242239 @default.
- W2056551165 cites W1990824174 @default.
- W2056551165 cites W1991173495 @default.
- W2056551165 cites W1997031801 @default.
- W2056551165 cites W2004380511 @default.
- W2056551165 cites W2008047653 @default.
- W2056551165 cites W2013524758 @default.
- W2056551165 cites W2018823764 @default.
- W2056551165 cites W2022275249 @default.
- W2056551165 cites W2030705868 @default.
- W2056551165 cites W2040164628 @default.
- W2056551165 cites W2040499694 @default.
- W2056551165 cites W2040922107 @default.
- W2056551165 cites W2048296798 @default.
- W2056551165 cites W2049551741 @default.
- W2056551165 cites W2050161506 @default.
- W2056551165 cites W2050230619 @default.
- W2056551165 cites W2052098936 @default.
- W2056551165 cites W2052190109 @default.
- W2056551165 cites W2052336689 @default.
- W2056551165 cites W2074897360 @default.
- W2056551165 cites W2076246669 @default.
- W2056551165 cites W2087538584 @default.
- W2056551165 cites W2089843122 @default.
- W2056551165 cites W2107755054 @default.
- W2056551165 cites W2108169091 @default.
- W2056551165 cites W2110343195 @default.
- W2056551165 cites W2119711772 @default.
- W2056551165 cites W2119851912 @default.
- W2056551165 cites W2122796918 @default.
- W2056551165 cites W2123584222 @default.
- W2056551165 cites W2123774216 @default.
- W2056551165 cites W2127442418 @default.
- W2056551165 cites W2128151309 @default.
- W2056551165 cites W2129579709 @default.
- W2056551165 cites W2132235563 @default.
- W2056551165 cites W2133392512 @default.
- W2056551165 cites W2134783591 @default.
- W2056551165 cites W2140660757 @default.
- W2056551165 cites W2142244624 @default.
- W2056551165 cites W2142642125 @default.
- W2056551165 cites W2143992683 @default.
- W2056551165 cites W2149791927 @default.
- W2056551165 cites W2157752701 @default.
- W2056551165 cites W2160756148 @default.
- W2056551165 cites W2161375784 @default.
- W2056551165 cites W2161633633 @default.
- W2056551165 cites W2161641617 @default.
- W2056551165 cites W2161891468 @default.
- W2056551165 cites W2162633534 @default.
- W2056551165 cites W2169728426 @default.
- W2056551165 cites W2315359669 @default.
- W2056551165 cites W2316943902 @default.
- W2056551165 cites W4237251694 @default.
- W2056551165 cites W4300119551 @default.
- W2056551165 doi "https://doi.org/10.1038/mp.2008.131" @default.
- W2056551165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19107115" @default.
- W2056551165 hasPublicationYear "2008" @default.
- W2056551165 type Work @default.
- W2056551165 sameAs 2056551165 @default.
- W2056551165 citedByCount "239" @default.
- W2056551165 countsByYear W20565511652012 @default.
- W2056551165 countsByYear W20565511652013 @default.
- W2056551165 countsByYear W20565511652014 @default.
- W2056551165 countsByYear W20565511652015 @default.
- W2056551165 countsByYear W20565511652016 @default.
- W2056551165 countsByYear W20565511652017 @default.