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- W2056551448 abstract "Release of endothelin-1 (ET-1) from the mesenteric arteries of Wistar rats with streptozotocin-induced diabetes (STZ-DM) rats and nondiabetic rats was measured by a specific enzyme immunoassay following purification using an immunoaffinity column. The mesenteric arteries from STZ-DM rats released a significantly higher amount of ET-1 as compared to control rats (35.8 ± 2.8 vs 14.9 ± 2.0 pg/1hr, p<0.05). The plasma level of ET-1 in STZ-DM rats was also elevated to a significant extent as compared to controls (5.1 ± 0.4 vs 3.0 ± 0.4 pg/ml, p<0.05). The systolic blood pressure of STZ-DM rats was significantly higher than of the controls (p<0.05). The increased level of plasma ET-1 as well as its release from the mesenteric artery of STZ-DM rats may suggest its release following damage to the endothelium caused by diabetes and/or by associated changes in blood pressure." @default.
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- W2056551448 date "1991-01-01" @default.
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- W2056551448 title "Production of endothelin-1 from the mesenteric arteries of streptozotocin-induced diabetic rats" @default.
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- W2056551448 doi "https://doi.org/10.1016/0024-3205(91)90611-e" @default.
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