FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056551683> ?p ?o ?g. }

• W2056551683 endingPage "750" @default.
• W2056551683 startingPage "739" @default.
• W2056551683 abstract "Epidemiological studies suggest that dietary PUFA may influence breast cancer progression. n -3 PUFA are generally known to exert antitumour effects, whereas reports relative to n -6 PUFA anti-carcinogen effects are controversial. Arachidonic acid (AA; 20 : 4 n − 6) and its metabolites have been shown to inhibit the growth of human breast cancer cell lines, even if the downstream mechanisms by which AA may influence carcinogenesis remain unresolved. We explored the molecular basis for AA influence on proliferation, signal transduction and apoptosis in two human breast cancer cell lines, MCF-7 and MDA-MB-231. In both cell lines AA inhibited cell growth in a dose-dependent manner, even if MDA-MB-231 was somewhat more growth-inhibited than MCF-7. AA decreased extracellular signal-regulated protein kinase 1/2 phosphorylation level, and positively modulated PPARγ and PPARα expression, with only a slight effect against PPARβ/δ. In addition, AA increased Bak (an apoptosis-regulating protein) expression and reduced procaspase-3 and -9 levels only in MDA-MB-231 cells, thus indicating that the growth inhibitory effect can be correlated with apoptosis induction. In both cell lines the use of a specific antagonist made it possible to establish a relationship between AA growth inhibitory effect and PPARα involvement. AA decreases cell proliferation most likely by inducing apoptosis in MDA-MB-231 cells, while in the MCF-7 cell line the growth inhibitory activity can be attributed to the inhibition of the signal transduction pathway involved in cell proliferation. In both cases, the results here presented suggest PPARα as a possible contributor to the growth inhibitory effect of AA." @default.
• W2056551683 created "2016-06-24" @default.
• W2056551683 creator A5040501332 @default.
• W2056551683 creator A5050608798 @default.
• W2056551683 creator A5065678199 @default.
• W2056551683 creator A5088236480 @default.
• W2056551683 creator A5090301911 @default.
• W2056551683 date "2008-10-01" @default.
• W2056551683 modified "2023-09-27" @default.
• W2056551683 title "Involvement of PPARα in the growth inhibitory effect of arachidonic acid on breast cancer cells" @default.
• W2056551683 cites W1562457256 @default.
• W2056551683 cites W1647126819 @default.
• W2056551683 cites W1764105371 @default.
• W2056551683 cites W1937834149 @default.
• W2056551683 cites W1967230525 @default.
• W2056551683 cites W1968980738 @default.
• W2056551683 cites W1969598086 @default.
• W2056551683 cites W1972605770 @default.
• W2056551683 cites W1978380407 @default.
• W2056551683 cites W1981833670 @default.
• W2056551683 cites W1993342645 @default.
• W2056551683 cites W1995324071 @default.
• W2056551683 cites W2000417191 @default.
• W2056551683 cites W2000996965 @default.
• W2056551683 cites W2001058901 @default.
• W2056551683 cites W2004454505 @default.
• W2056551683 cites W2008404887 @default.
• W2056551683 cites W2012277808 @default.
• W2056551683 cites W2014385323 @default.
• W2056551683 cites W2016075273 @default.
• W2056551683 cites W2021500692 @default.
• W2056551683 cites W2027833645 @default.
• W2056551683 cites W2035484670 @default.
• W2056551683 cites W2041352419 @default.
• W2056551683 cites W2047281776 @default.
• W2056551683 cites W2050635723 @default.
• W2056551683 cites W2065019417 @default.
• W2056551683 cites W2066585902 @default.
• W2056551683 cites W206748399 @default.
• W2056551683 cites W2081420631 @default.
• W2056551683 cites W2081449811 @default.
• W2056551683 cites W2082577848 @default.
• W2056551683 cites W2084287954 @default.
• W2056551683 cites W2086785259 @default.
• W2056551683 cites W2089687829 @default.
• W2056551683 cites W2091788870 @default.
• W2056551683 cites W2103971999 @default.
• W2056551683 cites W2124922239 @default.
• W2056551683 cites W2132674033 @default.
• W2056551683 cites W2134692293 @default.
• W2056551683 cites W2138904934 @default.
• W2056551683 cites W2149287982 @default.
• W2056551683 cites W2157639204 @default.
• W2056551683 cites W2158572006 @default.
• W2056551683 cites W2169082359 @default.
• W2056551683 cites W2183857205 @default.
• W2056551683 cites W2262311617 @default.
• W2056551683 cites W2402820619 @default.
• W2056551683 cites W4232306947 @default.
• W2056551683 doi "https://doi.org/10.1017/s0007114508942161" @default.
• W2056551683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18304389" @default.
• W2056551683 hasPublicationYear "2008" @default.
• W2056551683 type Work @default.
• W2056551683 sameAs 2056551683 @default.
• W2056551683 citedByCount "28" @default.
• W2056551683 countsByYear W20565516832012 @default.
• W2056551683 countsByYear W20565516832013 @default.
• W2056551683 countsByYear W20565516832014 @default.
• W2056551683 countsByYear W20565516832015 @default.
• W2056551683 countsByYear W20565516832016 @default.
• W2056551683 countsByYear W20565516832017 @default.
• W2056551683 countsByYear W20565516832018 @default.
• W2056551683 countsByYear W20565516832020 @default.
• W2056551683 countsByYear W20565516832021 @default.
• W2056551683 countsByYear W20565516832022 @default.
• W2056551683 countsByYear W20565516832023 @default.
• W2056551683 crossrefType "journal-article" @default.
• W2056551683 hasAuthorship W2056551683A5040501332 @default.
• W2056551683 hasAuthorship W2056551683A5050608798 @default.
• W2056551683 hasAuthorship W2056551683A5065678199 @default.
• W2056551683 hasAuthorship W2056551683A5088236480 @default.
• W2056551683 hasAuthorship W2056551683A5090301911 @default.
• W2056551683 hasBestOaLocation W20565516831 @default.
• W2056551683 hasConcept C104317684 @default.
• W2056551683 hasConcept C121608353 @default.
• W2056551683 hasConcept C126322002 @default.
• W2056551683 hasConcept C134018914 @default.
• W2056551683 hasConcept C181199279 @default.
• W2056551683 hasConcept C190283241 @default.
• W2056551683 hasConcept C2778078955 @default.
• W2056551683 hasConcept C2779707156 @default.
• W2056551683 hasConcept C502942594 @default.
• W2056551683 hasConcept C54355233 @default.
• W2056551683 hasConcept C55493867 @default.
• W2056551683 hasConcept C555283112 @default.
• W2056551683 hasConcept C62112901 @default.
• W2056551683 hasConcept C62478195 @default.
• W2056551683 hasConcept C71924100 @default.

• next