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- W2056551767 abstract "EHD1 regulates the trafficking of multiple receptors from the endocytic recycling compartment (ERC) to the plasma membrane. However, the potential role of EHD1 in regulating the family of glycosylphosphatidylinositol-anchored proteins (GPI-APs) has not been determined. Here we demonstrate a novel role for EHD1 in regulating the trafficking of CD59, an endogenous GPI-AP, at early stages of trafficking through the endocytic pathway. EHD1 displays significant colocalization with newly internalized CD59. Upon EHD1 depletion, there is a rapid Rab5-independent coalescence of CD59 in the ERC region. However, expression of an active Arf6 mutant (Q67L), which traps internalized pre-sorting endosomal cargo in phosphatidylinositol(4,5)-bisphosphate enriched vacuoles, prevents this coalescence. It is of interest that sustained PKC activation leads to a similar coalescence of CD59 at the ERC, and treatment of EHD1-depleted cells with a PKC inhibitor (Go6976) blocked this rapid relocation of CD59. However, unlike sustained PKC activation, EHD1 depletion does not induce the translocation of PKCα to ERC. The results presented herein provide evidence that EHD1 is involved in the control of CD59 transport from pre-sorting endosomes to the ERC in a PKC-dependent manner. However, the mechanisms of EHD1-induced coalescence of CD59 at the ERC differ from those induced by sustained PKC activation." @default.
- W2056551767 created "2016-06-24" @default.
- W2056551767 creator A5037356338 @default.
- W2056551767 creator A5071573004 @default.
- W2056551767 creator A5085276533 @default.
- W2056551767 creator A5091286376 @default.
- W2056551767 date "2010-11-12" @default.
- W2056551767 modified "2023-10-17" @default.
- W2056551767 title "Pre-Sorting Endosomal Transport of the GPI-Anchored Protein, CD59, is Regulated by EHD1" @default.
- W2056551767 cites W1487172145 @default.
- W2056551767 cites W1513237282 @default.
- W2056551767 cites W1531834763 @default.
- W2056551767 cites W1548405860 @default.
- W2056551767 cites W1557545815 @default.
- W2056551767 cites W1565184249 @default.
- W2056551767 cites W1587363777 @default.
- W2056551767 cites W1595083713 @default.
- W2056551767 cites W1606338704 @default.
- W2056551767 cites W1895535125 @default.
- W2056551767 cites W1948503740 @default.
- W2056551767 cites W1960120498 @default.
- W2056551767 cites W1974829226 @default.
- W2056551767 cites W1977253956 @default.
- W2056551767 cites W1977523984 @default.
- W2056551767 cites W1978427724 @default.
- W2056551767 cites W1983691362 @default.
- W2056551767 cites W1987339168 @default.
- W2056551767 cites W1991113810 @default.
- W2056551767 cites W1992868764 @default.
- W2056551767 cites W1996453362 @default.
- W2056551767 cites W2003180539 @default.
- W2056551767 cites W2005476919 @default.
- W2056551767 cites W2005574904 @default.
- W2056551767 cites W2007171704 @default.
- W2056551767 cites W2009015720 @default.
- W2056551767 cites W2009468127 @default.
- W2056551767 cites W2017888097 @default.
- W2056551767 cites W2018177365 @default.
- W2056551767 cites W2018435413 @default.
- W2056551767 cites W2024426605 @default.
- W2056551767 cites W2026843617 @default.
- W2056551767 cites W2027200751 @default.
- W2056551767 cites W2030911091 @default.
- W2056551767 cites W2032335304 @default.
- W2056551767 cites W2034913511 @default.
- W2056551767 cites W2038404508 @default.
- W2056551767 cites W2046045564 @default.
- W2056551767 cites W2050291058 @default.
- W2056551767 cites W2050366072 @default.
- W2056551767 cites W2051974311 @default.
- W2056551767 cites W2052976709 @default.
- W2056551767 cites W2054077177 @default.
- W2056551767 cites W2059346525 @default.
- W2056551767 cites W2059547846 @default.
- W2056551767 cites W2064880862 @default.
- W2056551767 cites W2069361948 @default.
- W2056551767 cites W2072246040 @default.
- W2056551767 cites W2076185491 @default.
- W2056551767 cites W2085271514 @default.
- W2056551767 cites W2087728854 @default.
- W2056551767 cites W2088565025 @default.
- W2056551767 cites W2089778398 @default.
- W2056551767 cites W2104391163 @default.
- W2056551767 cites W2111407536 @default.
- W2056551767 cites W2112751496 @default.
- W2056551767 cites W2112913092 @default.
- W2056551767 cites W2114370335 @default.
- W2056551767 cites W2119462245 @default.
- W2056551767 cites W2120920292 @default.
- W2056551767 cites W2125163545 @default.
- W2056551767 cites W2128208230 @default.
- W2056551767 cites W2130827336 @default.
- W2056551767 cites W2135149818 @default.
- W2056551767 cites W2135404068 @default.
- W2056551767 cites W2137960852 @default.
- W2056551767 cites W2146015738 @default.
- W2056551767 cites W2151462825 @default.
- W2056551767 cites W2155274044 @default.
- W2056551767 cites W2155609833 @default.
- W2056551767 cites W2155890999 @default.
- W2056551767 cites W2156130718 @default.
- W2056551767 cites W2159447933 @default.
- W2056551767 cites W2160350590 @default.
- W2056551767 cites W2161591620 @default.
- W2056551767 cites W2166135064 @default.
- W2056551767 cites W2166193953 @default.
- W2056551767 cites W2168548277 @default.
- W2056551767 cites W2168787707 @default.
- W2056551767 cites W2169215981 @default.
- W2056551767 cites W2170250011 @default.
- W2056551767 doi "https://doi.org/10.1111/j.1600-0854.2010.01135.x" @default.
- W2056551767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20961375" @default.
- W2056551767 hasPublicationYear "2010" @default.
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