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- W2056551991 abstract "During the embryonic development of the central nervous system, neuroepithelial cells act as neural stem cells. They undergo interkinetic nuclear movements along their apico-basal axis during the cell cycle. The neuroepithelial cell shows robust increases in the nucleoplasmic [Ca 2+ ] in response to G protein-coupled receptor activation in S-phase, during which the nucleus is located in the basal region of the neuroepithelial cell. This response is caused by Ca 2+ release from intracellular Ca 2+ stores, which are comprised of the endoplasmic reticulum and the nuclear envelope. The Ca 2+ release leads to the activation of Ca 2+ entry from the extracellular space, which is called capacitative, or store-operated Ca 2+ entry. These movements of Ca 2+ are essential for DNA synthesis during S-phase. Spontaneous Ca 2+ oscillations also occur synchronously across the cells. This synchronization is mediated by voltage fluctuations in the membrane potential of the nuclear envelope due to Ca 2+ release and the counter movement of K + ions; the voltage fluctuation induces alternating current (AC), which is transmitted via capacitative electrical coupling to the neighboring cells. The membrane potential across the plasma membrane is stabilized through gap junction coupling by lowering the input resistance. Thus, stored Ca 2+ ions are a key player in the maintenance of the cellular activity of neuroepithelial cells." @default.
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- W2056551991 date "2012-01-01" @default.
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- W2056551991 title "Ion Channel Activities in Neural Stem Cells of the Neuroepithelium" @default.
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- W2056551991 doi "https://doi.org/10.1155/2012/247670" @default.
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