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- W2056552443 abstract "Aortic stenosis is the most common valvular heart disease. Bicuspid aortic valves (BAV) calcify rapidly and are generally much more remodeled than tricuspid valves. Indeed, in BAV, cells are exposed to a high mechanical stress. In turn, mechanical stress can activate/inhibit cell signaling pathways. Objective: In this study, we hypothesized that mechanical stress could act as an important regulator of cell calcification in the aortic valve. To test our hypothesis, we exposed vascular interstitial cells (VICs) isolated from human aortic valves to cyclic stretches in the presence of calcifying medium. Our results showed that exposure of VICs cultures to mechanical stress causes a considerable increase in calcification. Observation of cells by scanning electron microscopy shows that this increase in calcification is associated with a change in morphology. Indeed, tension causes a significant decrease in cell size (p = 0.02) and is associated with calcium intracellular deposits. Comparative analysis of bicuspid and tricuspid valves by scanning electron microscopy establishes that the ventricular side of the bicuspid valve is massively stripped from endothelium compared with the tricuspid valve. This suggests that bicuspid valves are exposed to a much higher mechanical stress. Furthermore, we found that mechanical stress increases the expression of osteoblastic genes involved in the regulation of phosphate metabolism. These results support a role for mechanical stress in the regulation of calcification and suggest that mechanical forces could, at least in part, explain the early and rapid mineralization of bicuspid valves." @default.
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- W2056552443 date "2012-09-01" @default.
- W2056552443 modified "2023-10-16" @default.
- W2056552443 title "317 Mechanical Stress Enhances Aortic Valve Calcification: Implication For Bicuspid Aortic Valve Mineralization" @default.
- W2056552443 doi "https://doi.org/10.1016/j.cjca.2012.07.298" @default.
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