Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056552659> ?p ?o ?g. }
- W2056552659 endingPage "863" @default.
- W2056552659 startingPage "852" @default.
- W2056552659 abstract "The heat shock proteins ClpC and ClpP are subunits of an ATP-dependent protease of Bacillus subtilis. Under non-stressed conditions, transcription of the clpC and clpP genes is negatively regulated by CtsR, the global repressor of clp gene expression. Here, CtsR was proven to be a specific substrate of the ClpCP protease under stress conditions. Two proteins of former unknown function, McsA and McsB, which are also encoded by the clpC operon, act as modulators of CtsR repression. McsA containing zinc finger motifs stabilizes CtsR under non-stressed conditions. McsB, a putative kinase, can inactivate CtsR by modification to remove the repressor from the DNA and to target CtsR for degradation by the ClpCP protease during stress. Thus, clp gene expression in Gram-positive bacteria is autoregulated by a novel mechanism of controlled proteolysis, a circuit of down-regulation by stabilization and protection of a transcription repressor, and induction by presenting the repressor to the protease. Thereby, the ClpC ATPase, a member of the Hsp100 family, was identified as a positive regulator of the heat shock response." @default.
- W2056552659 created "2016-06-24" @default.
- W2056552659 creator A5081388753 @default.
- W2056552659 date "2001-02-15" @default.
- W2056552659 modified "2023-10-05" @default.
- W2056552659 title "Clp-mediated proteolysis in Gram-positive bacteria is autoregulated by the stability of a repressor" @default.
- W2056552659 cites W1539516473 @default.
- W2056552659 cites W1539601278 @default.
- W2056552659 cites W1564936970 @default.
- W2056552659 cites W1570922221 @default.
- W2056552659 cites W1598801131 @default.
- W2056552659 cites W1823447345 @default.
- W2056552659 cites W1873199501 @default.
- W2056552659 cites W1904178031 @default.
- W2056552659 cites W1928629620 @default.
- W2056552659 cites W1964118366 @default.
- W2056552659 cites W1967138582 @default.
- W2056552659 cites W1968000268 @default.
- W2056552659 cites W1969766795 @default.
- W2056552659 cites W1983345237 @default.
- W2056552659 cites W1990148399 @default.
- W2056552659 cites W1993515258 @default.
- W2056552659 cites W1996490581 @default.
- W2056552659 cites W1999062010 @default.
- W2056552659 cites W1999467171 @default.
- W2056552659 cites W2003583007 @default.
- W2056552659 cites W2008561447 @default.
- W2056552659 cites W2012054900 @default.
- W2056552659 cites W2012547722 @default.
- W2056552659 cites W2013943606 @default.
- W2056552659 cites W2018289835 @default.
- W2056552659 cites W2020294551 @default.
- W2056552659 cites W2021040301 @default.
- W2056552659 cites W2023614501 @default.
- W2056552659 cites W2024091788 @default.
- W2056552659 cites W2024154483 @default.
- W2056552659 cites W2029020949 @default.
- W2056552659 cites W2031790892 @default.
- W2056552659 cites W2046882513 @default.
- W2056552659 cites W2052696818 @default.
- W2056552659 cites W2058415888 @default.
- W2056552659 cites W2072327561 @default.
- W2056552659 cites W2080928558 @default.
- W2056552659 cites W2081373054 @default.
- W2056552659 cites W2084140927 @default.
- W2056552659 cites W2088114354 @default.
- W2056552659 cites W2089865526 @default.
- W2056552659 cites W2092189990 @default.
- W2056552659 cites W2098883789 @default.
- W2056552659 cites W2099196052 @default.
- W2056552659 cites W2100837269 @default.
- W2056552659 cites W2100975834 @default.
- W2056552659 cites W2104178065 @default.
- W2056552659 cites W2107824577 @default.
- W2056552659 cites W2115703815 @default.
- W2056552659 cites W2126018533 @default.
- W2056552659 cites W2128635872 @default.
- W2056552659 cites W2129606026 @default.
- W2056552659 cites W2130412668 @default.
- W2056552659 cites W2134915935 @default.
- W2056552659 cites W2139058438 @default.
- W2056552659 cites W2148736799 @default.
- W2056552659 cites W2155608445 @default.
- W2056552659 cites W2157974567 @default.
- W2056552659 cites W2160376149 @default.
- W2056552659 cites W2463267938 @default.
- W2056552659 doi "https://doi.org/10.1093/emboj/20.4.852" @default.
- W2056552659 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/145420" @default.
- W2056552659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11179229" @default.
- W2056552659 hasPublicationYear "2001" @default.
- W2056552659 type Work @default.
- W2056552659 sameAs 2056552659 @default.
- W2056552659 citedByCount "143" @default.
- W2056552659 countsByYear W20565526592012 @default.
- W2056552659 countsByYear W20565526592013 @default.
- W2056552659 countsByYear W20565526592014 @default.
- W2056552659 countsByYear W20565526592015 @default.
- W2056552659 countsByYear W20565526592016 @default.
- W2056552659 countsByYear W20565526592017 @default.
- W2056552659 countsByYear W20565526592018 @default.
- W2056552659 countsByYear W20565526592019 @default.
- W2056552659 countsByYear W20565526592020 @default.
- W2056552659 countsByYear W20565526592021 @default.
- W2056552659 countsByYear W20565526592022 @default.
- W2056552659 countsByYear W20565526592023 @default.
- W2056552659 crossrefType "journal-article" @default.
- W2056552659 hasAuthorship W2056552659A5081388753 @default.
- W2056552659 hasBestOaLocation W20565526591 @default.
- W2056552659 hasConcept C104317684 @default.
- W2056552659 hasConcept C137984847 @default.
- W2056552659 hasConcept C138885662 @default.
- W2056552659 hasConcept C150194340 @default.
- W2056552659 hasConcept C158448853 @default.
- W2056552659 hasConcept C179926584 @default.
- W2056552659 hasConcept C181199279 @default.
- W2056552659 hasConcept C186310378 @default.
- W2056552659 hasConcept C203075996 @default.
- W2056552659 hasConcept C205260736 @default.