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• W2056553580 abstract "Objective: The aim of this study was to determine the value of US assessment before excision or core biopsy of the clustered microcalcifications.Methods: 28 consecutive patients who underwent excision biopsy (27 mammographic and 1 US guidance) for the clustered microcalcifications during the past one year period were included. US visibility of the microcalcifications was assessed, and accompanied structural abnormalities were correlated with histology. Ductal involvement was considered irregular and aggressive in US if there was either uneven epithelial hyperplasia, distorsion, ill-defined heterogeneous echogenicity, or intraductal clumped microcalcifications. Prospective and retrospective analysis included evaluation for the presence of any of the former 3 and 4 items, respectively. Mammography with metallic marker was implemented during the second half of the study to aid US identification of the microcalcifications in some cases.Results: 7 DCIS, 2 atypical ductal hyperplasia (ADH), 6 DH, 1 fibroadenomatoid hyperplasia (FAH), and 12 fibrocystic changes (FC) were confirmed by histology. For all lesions, US achieved a sensitivity of 89% (25/28) in the detection of microcalcifications. The detection rate for microcalcifications in aggressive lesions was 78% (missed detection in 2 peripheral ADH) and in benign lesions 95% (18/19). (Implementation of mammography with metallic marker during the second half of the study prevented from further missed detections of the microcalcifications in 2 DCIS and 1 FC.) Excluding the 2 ADH and 1 FC with missed detections of the microcalcifications, the irregular ductal structure associated with the microcalcifications was seen in 5 DCIS (71% sensitivity), prospectively and 6 DCIS (86% sensitivity), retrospectively. The specificity was 89% (falsely recognized in benign mimickers consisting of 1 FAH and 1 DH with adenosis).Conclusions: The value of US may be currently limited to evaluation of the accompanied structural abnormalities before undergoing invasive diagnostic procedures for the clustered microcalcifications. Further study is needed to determine if there is a possibility that the identification of US abnormalities may serve as a guide in decision making for or against the excision (or core) biopsy of the microcalcifications. Objective: The aim of this study was to determine the value of US assessment before excision or core biopsy of the clustered microcalcifications. Methods: 28 consecutive patients who underwent excision biopsy (27 mammographic and 1 US guidance) for the clustered microcalcifications during the past one year period were included. US visibility of the microcalcifications was assessed, and accompanied structural abnormalities were correlated with histology. Ductal involvement was considered irregular and aggressive in US if there was either uneven epithelial hyperplasia, distorsion, ill-defined heterogeneous echogenicity, or intraductal clumped microcalcifications. Prospective and retrospective analysis included evaluation for the presence of any of the former 3 and 4 items, respectively. Mammography with metallic marker was implemented during the second half of the study to aid US identification of the microcalcifications in some cases. Results: 7 DCIS, 2 atypical ductal hyperplasia (ADH), 6 DH, 1 fibroadenomatoid hyperplasia (FAH), and 12 fibrocystic changes (FC) were confirmed by histology. For all lesions, US achieved a sensitivity of 89% (25/28) in the detection of microcalcifications. The detection rate for microcalcifications in aggressive lesions was 78% (missed detection in 2 peripheral ADH) and in benign lesions 95% (18/19). (Implementation of mammography with metallic marker during the second half of the study prevented from further missed detections of the microcalcifications in 2 DCIS and 1 FC.) Excluding the 2 ADH and 1 FC with missed detections of the microcalcifications, the irregular ductal structure associated with the microcalcifications was seen in 5 DCIS (71% sensitivity), prospectively and 6 DCIS (86% sensitivity), retrospectively. The specificity was 89% (falsely recognized in benign mimickers consisting of 1 FAH and 1 DH with adenosis). Conclusions: The value of US may be currently limited to evaluation of the accompanied structural abnormalities before undergoing invasive diagnostic procedures for the clustered microcalcifications. Further study is needed to determine if there is a possibility that the identification of US abnormalities may serve as a guide in decision making for or against the excision (or core) biopsy of the microcalcifications." @default.
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• W2056553580 date "2003-05-01" @default.
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• W2056553580 title "Clustered microcalcifications: the value of pre-biopsy assessment using US" @default.
• W2056553580 doi "https://doi.org/10.1016/s0301-5629(03)00749-x" @default.
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