FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056553691> ?p ?o ?g. }

• W2056553691 endingPage "203" @default.
• W2056553691 startingPage "196" @default.
• W2056553691 abstract "thrombolytic treatment with tissue plasminogen activator (tPA) improves outcome of patients with stroke who can be treated within 3 hours of symptom onset. However, delayed treatment with tPA leads to increased risk of hemorrhagic transformation and can result in enhanced brain injury. The purpose of this study is to validate a reproducible mouse model of hemorrhagic transformation associated with delayed administration of tPA.mice were anesthetized and thrombin was injected into the middle cerebral artery to induce the formation of a clot as described by Orset et al. To induce reperfusion, tPA (10 mg/kg) was intravenously administered 20 minutes or 3 hours after thrombin injection.thrombin produced a clot in 83.1% of the animals, which caused focal ischemia determined 24 hours after the injection. Different degrees of bleeding were found in the middle cerebral artery occlusion group, including hemorrhagic infarction type 1 (HI-1) in 46.2%, hemorrhagic infarction type 2 (HI-2) in 30.8% and parenchymal hemorrhage type 1 in 23.0%. Administration of tPA 20 minutes after the occlusion produced an effective reperfusion in 62.5% of the animals and reduced both infarct volume and appearance of severe hemorrhage (10% nonhemorrhage, 80% HI-1 and 10% HI-2). However, administration of tPA 3 hours after the occlusion led to effective reperfusion in 47.1% of the animals, did not reduce infarct volume, caused hemorrhagic transformation (25% HI-1, 37.5% HI-2, and 37.5% parenchymal hemorrhage type 1), and increased hemorrhage and brain swelling.we have set up a reproducible mouse model of hemorrhagic transformation associated with delayed administration of tPA similar to that observed in humans." @default.
• W2056553691 created "2016-06-24" @default.
• W2056553691 creator A5000871439 @default.
• W2056553691 creator A5016967825 @default.
• W2056553691 creator A5018666013 @default.
• W2056553691 creator A5019880814 @default.
• W2056553691 creator A5020184761 @default.
• W2056553691 creator A5021227220 @default.
• W2056553691 creator A5034339300 @default.
• W2056553691 creator A5060792245 @default.
• W2056553691 creator A5061456960 @default.
• W2056553691 date "2011-01-01" @default.
• W2056553691 modified "2023-09-30" @default.
• W2056553691 title "A Mouse Model of Hemorrhagic Transformation by Delayed Tissue Plasminogen Activator Administration After In Situ Thromboembolic Stroke" @default.
• W2056553691 cites W1594129908 @default.
• W2056553691 cites W1974659269 @default.
• W2056553691 cites W1976733602 @default.
• W2056553691 cites W1998907224 @default.
• W2056553691 cites W2004287928 @default.
• W2056553691 cites W2031945226 @default.
• W2056553691 cites W2036204238 @default.
• W2056553691 cites W2049692362 @default.
• W2056553691 cites W205495280 @default.
• W2056553691 cites W2070198884 @default.
• W2056553691 cites W2077480873 @default.
• W2056553691 cites W2097782316 @default.
• W2056553691 cites W2112505121 @default.
• W2056553691 cites W2116725740 @default.
• W2056553691 cites W2122342801 @default.
• W2056553691 cites W2125065324 @default.
• W2056553691 cites W2127366468 @default.
• W2056553691 cites W2129357435 @default.
• W2056553691 cites W2138760592 @default.
• W2056553691 cites W2139714668 @default.
• W2056553691 cites W2148207944 @default.
• W2056553691 cites W2153891187 @default.
• W2056553691 cites W2159233098 @default.
• W2056553691 cites W2164566148 @default.
• W2056553691 cites W2165873031 @default.
• W2056553691 cites W2170884381 @default.
• W2056553691 cites W2292308933 @default.
• W2056553691 cites W4243036851 @default.
• W2056553691 doi "https://doi.org/10.1161/strokeaha.110.600452" @default.
• W2056553691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21106952" @default.
• W2056553691 hasPublicationYear "2011" @default.
• W2056553691 type Work @default.
• W2056553691 sameAs 2056553691 @default.
• W2056553691 citedByCount "68" @default.
• W2056553691 countsByYear W20565536912012 @default.
• W2056553691 countsByYear W20565536912013 @default.
• W2056553691 countsByYear W20565536912014 @default.
• W2056553691 countsByYear W20565536912015 @default.
• W2056553691 countsByYear W20565536912016 @default.
• W2056553691 countsByYear W20565536912017 @default.
• W2056553691 countsByYear W20565536912018 @default.
• W2056553691 countsByYear W20565536912019 @default.
• W2056553691 countsByYear W20565536912020 @default.
• W2056553691 countsByYear W20565536912021 @default.
• W2056553691 countsByYear W20565536912022 @default.
• W2056553691 countsByYear W20565536912023 @default.
• W2056553691 crossrefType "journal-article" @default.
• W2056553691 hasAuthorship W2056553691A5000871439 @default.
• W2056553691 hasAuthorship W2056553691A5016967825 @default.
• W2056553691 hasAuthorship W2056553691A5018666013 @default.
• W2056553691 hasAuthorship W2056553691A5019880814 @default.
• W2056553691 hasAuthorship W2056553691A5020184761 @default.
• W2056553691 hasAuthorship W2056553691A5021227220 @default.
• W2056553691 hasAuthorship W2056553691A5034339300 @default.
• W2056553691 hasAuthorship W2056553691A5060792245 @default.
• W2056553691 hasAuthorship W2056553691A5061456960 @default.
• W2056553691 hasBestOaLocation W20565536911 @default.
• W2056553691 hasConcept C126322002 @default.
• W2056553691 hasConcept C127413603 @default.
• W2056553691 hasConcept C142724271 @default.
• W2056553691 hasConcept C164705383 @default.
• W2056553691 hasConcept C196822366 @default.
• W2056553691 hasConcept C2775841333 @default.
• W2056553691 hasConcept C2776268601 @default.
• W2056553691 hasConcept C2776572282 @default.
• W2056553691 hasConcept C2777798775 @default.
• W2056553691 hasConcept C2779450755 @default.
• W2056553691 hasConcept C2779679481 @default.
• W2056553691 hasConcept C2780645631 @default.
• W2056553691 hasConcept C42219234 @default.
• W2056553691 hasConcept C500558357 @default.
• W2056553691 hasConcept C541997718 @default.
• W2056553691 hasConcept C71924100 @default.
• W2056553691 hasConcept C78519656 @default.
• W2056553691 hasConceptScore W2056553691C126322002 @default.
• W2056553691 hasConceptScore W2056553691C127413603 @default.
• W2056553691 hasConceptScore W2056553691C142724271 @default.
• W2056553691 hasConceptScore W2056553691C164705383 @default.
• W2056553691 hasConceptScore W2056553691C196822366 @default.
• W2056553691 hasConceptScore W2056553691C2775841333 @default.
• W2056553691 hasConceptScore W2056553691C2776268601 @default.
• W2056553691 hasConceptScore W2056553691C2776572282 @default.
• W2056553691 hasConceptScore W2056553691C2777798775 @default.
• W2056553691 hasConceptScore W2056553691C2779450755 @default.

• next