FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056554837> ?p ?o ?g. }

• W2056554837 endingPage "255" @default.
• W2056554837 startingPage "243" @default.
• W2056554837 abstract "Pelargonium sidoides DC. (Geraniaceae), a popular medicinal plant used in traditional medicine in the treatment of gastrointestinal ailments has been transformed into a phytopharmaceutical (EPs® 7360) for treating respiratory tract infections. The increasing international demand for Pelargonium sidoides has led to localised overexploitation of its wild populations in southern Africa. The aim of the review is to provide a synthesis of the current state of scientific knowledge on the phytochemical, pharmacological and toxicological properties of Pelargonium sidoides as well as the potential role of plant biotechnology in its conservation. The review highlights knowledge gaps in these research areas. A comprehensive literature search involving mainly electronic and library sources of information were used to collate and synthesise published data. Experimental results from in vitro studies indicate that bioactive phytochemical constituents of Pelargonium sidoides may not possess a direct antimicrobial effect, but instead act by interfering with microbial binding to host cell receptors, inhibition of key enzymes and the production of antimicrobial effector molecules such as nitric oxide and interferons (IFNs) by the host cells. Furthermore, clinical evaluations in randomised, double-blind, placebo-controlled trials have demonstrated the beneficial effect of Pelargonium sidoides in the treatment of respiratory tract infections with few side effects. However, there is lack of adequate information on the safety evaluation of the plant. On the other hand, the increasing demand for Pelargonium sidoides has led to localised illegal harvesting of wild plants. Pharmacological data reported in literature suggest that Pelargonium sidoides shows a beneficial effect in the treatment of respiratory tract infections. However, more studies are required to elucidate the mode of action of the active constituents exhibited in the treatment of respiratory tract infections and other health conditions caused by microbial attack. Furthermore, the pharmacological usefulness of Pelargonium sidoides must take cognisance of the broader context involving the need for conservation-friendly approaches in its utilisation. In this regard, plant biotechnology applications can play a meaningful role in a holistic conservation strategy." @default.
• W2056554837 created "2016-06-24" @default.
• W2056554837 creator A5053858509 @default.
• W2056554837 creator A5088582956 @default.
• W2056554837 date "2014-03-01" @default.
• W2056554837 modified "2023-10-11" @default.
• W2056554837 title "Medicinal properties and conservation of Pelargonium sidoides DC." @default.
• W2056554837 cites W1917419250 @default.
• W2056554837 cites W1970018433 @default.
• W2056554837 cites W1971873613 @default.
• W2056554837 cites W1973260333 @default.
• W2056554837 cites W1976772467 @default.
• W2056554837 cites W1976850456 @default.
• W2056554837 cites W1979535592 @default.
• W2056554837 cites W1979861676 @default.
• W2056554837 cites W1981809568 @default.
• W2056554837 cites W1983907449 @default.
• W2056554837 cites W1984481392 @default.
• W2056554837 cites W1985000240 @default.
• W2056554837 cites W1993941779 @default.
• W2056554837 cites W1994907658 @default.
• W2056554837 cites W1995080434 @default.
• W2056554837 cites W1996026064 @default.
• W2056554837 cites W1998925504 @default.
• W2056554837 cites W2005854408 @default.
• W2056554837 cites W2008748583 @default.
• W2056554837 cites W2009118140 @default.
• W2056554837 cites W2011422692 @default.
• W2056554837 cites W2012230438 @default.
• W2056554837 cites W2012326655 @default.
• W2056554837 cites W2015029862 @default.
• W2056554837 cites W2017330587 @default.
• W2056554837 cites W2018282326 @default.
• W2056554837 cites W2022243910 @default.
• W2056554837 cites W2022739973 @default.
• W2056554837 cites W2023426291 @default.
• W2056554837 cites W2027973783 @default.
• W2056554837 cites W2029237843 @default.
• W2056554837 cites W2031872616 @default.
• W2056554837 cites W2032022597 @default.
• W2056554837 cites W2033474069 @default.
• W2056554837 cites W2035679690 @default.
• W2056554837 cites W2036957401 @default.
• W2056554837 cites W2038670572 @default.
• W2056554837 cites W2039171270 @default.
• W2056554837 cites W2044653546 @default.
• W2056554837 cites W2044977925 @default.
• W2056554837 cites W2051259990 @default.
• W2056554837 cites W2055398396 @default.
• W2056554837 cites W2056931869 @default.
• W2056554837 cites W2064073012 @default.
• W2056554837 cites W2070357639 @default.
• W2056554837 cites W2072658091 @default.
• W2056554837 cites W2073132923 @default.
• W2056554837 cites W2074400209 @default.
• W2056554837 cites W2076329791 @default.
• W2056554837 cites W2077351842 @default.
• W2056554837 cites W2077658138 @default.
• W2056554837 cites W2079667112 @default.
• W2056554837 cites W2081237280 @default.
• W2056554837 cites W2081906965 @default.
• W2056554837 cites W2082539698 @default.
• W2056554837 cites W2086670976 @default.
• W2056554837 cites W2086935550 @default.
• W2056554837 cites W2108441155 @default.
• W2056554837 cites W2136398883 @default.
• W2056554837 cites W2150308482 @default.
• W2056554837 cites W2152825492 @default.
• W2056554837 cites W2160205706 @default.
• W2056554837 cites W2161512936 @default.
• W2056554837 cites W2163273380 @default.
• W2056554837 cites W2163446105 @default.
• W2056554837 cites W2163539844 @default.
• W2056554837 cites W2165425212 @default.
• W2056554837 cites W2168930459 @default.
• W2056554837 cites W2240518514 @default.
• W2056554837 cites W32743513 @default.
• W2056554837 doi "https://doi.org/10.1016/j.jep.2014.01.009" @default.
• W2056554837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7127097" @default.
• W2056554837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24463034" @default.
• W2056554837 hasPublicationYear "2014" @default.
• W2056554837 type Work @default.
• W2056554837 sameAs 2056554837 @default.
• W2056554837 citedByCount "65" @default.
• W2056554837 countsByYear W20565548372015 @default.
• W2056554837 countsByYear W20565548372016 @default.
• W2056554837 countsByYear W20565548372017 @default.
• W2056554837 countsByYear W20565548372018 @default.
• W2056554837 countsByYear W20565548372019 @default.
• W2056554837 countsByYear W20565548372020 @default.
• W2056554837 countsByYear W20565548372021 @default.
• W2056554837 countsByYear W20565548372022 @default.
• W2056554837 countsByYear W20565548372023 @default.
• W2056554837 crossrefType "journal-article" @default.
• W2056554837 hasAuthorship W2056554837A5053858509 @default.
• W2056554837 hasAuthorship W2056554837A5088582956 @default.
• W2056554837 hasBestOaLocation W20565548371 @default.
• W2056554837 hasConcept C195475562 @default.

• next