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- W2056555829 abstract "Treatment with highly active antiretroviral therapy (HAART) has been shown to modify viral replication dynamics and lead to a significant recovery of CD4 T-cells. A retrospective multicentre observational study was performed in a non-study population of 151 HIV-1-infected children, categorized into four groups according to therapy: untreated (NT). on monotherapy (MT) with a nucleoside inhibitor, on combination therapy (CT) with two nucleoside inhibitors, and on HAART, protease inhibitor containing regimens, to assess the real-life effectiveness of these different therapies on plasma viral load (VL) and CD4 + T-cells. VL was quantified using a standard molecular assay. CD4 + and CD8 + T-cells subsets were determined by flow cytometry. The HAART group showed the highest relative proportion (RP) of increases in 5, 10, 15 and 20% of CD4 + T-cells over baseline, and the earliest fall-off of VL (0.5, 1, 1.5 and 2 log 10 copies nil -1 ). The RP of the fall-off of 0.5, 1, 1.5 and 2 log 10 VL below baseline was 3-fold higher in HAART group than in the MT and CT groups. However, no differences were found among the groups of treated children in reaching undetectable VL. Conclusion: A better evolution of VL and CD4 + T-cells was evident in children on HAART, indicating a positive effect on the immune system and clinical status, inhibiting HIV-1 replication and enabling the recovery of CD4 + T-cell counts." @default.
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- W2056555829 date "2007-01-02" @default.
- W2056555829 modified "2023-10-18" @default.
- W2056555829 title "Dynamics of progression markers in a non-study population of human immunodeficiency virus-1 vertically infected infants with different antiretroviral treatments" @default.
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- W2056555829 doi "https://doi.org/10.1111/j.1651-2227.2002.tb03326.x" @default.
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