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- W2056556436 abstract "1. Organ cultures of parathyroid gland tissue of man, mouse, and 1012-day-old chicken embryos were cultivated in direct contact with fragments taken from the central area of the parietal bone anlagen of nearly full-term mouse embryos. 2. Parathyroid tissue of the three species was found capable of inducing and/or stimulating a process of lacunar resorption in the bone tissue. 3. Multinuclear osteoclasts always accompanied the process of lacunar resorption. Characteristic types of movement of osteoclasts are described. 4. Addition to the bone explants of a small amount of culture medium in which parathyroid tissue had been cultivated for some days induced a similar reaction. 5. Addition of parathormone (4-0.04 USP units per cubic centimeter of medium) also resulted in a similar reaction, suggesting that organ cultures of parathyroid tissue are capable of releasing a parathormone-like agent. 6. It is suggested that parathormone is indispensable for creating the conditions favoring the survival, the formation, and the functioning of osteoclasts. 7. Arguments are given favoring the idea that osteoclasts act by the way of a secretory activity, and not by a process of phagocytosis. 8. Explants from the peripheral (youngest) areas of the parietal bone anlagen did not react with a lacunar resorption if parathormone was added to the culture medium. 9. It is suggested that the lack of lacunar resorption in explants from the peripheral areas is correlated with the physiological absence of multinuclear osteoclasts." @default.
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- W2056556436 date "1959-06-01" @default.
- W2056556436 modified "2023-09-23" @default.
- W2056556436 title "Parathyroid gland and bone in vitro. VI" @default.
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- W2056556436 doi "https://doi.org/10.1016/0012-1606(59)90024-7" @default.
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