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- W2056556982 abstract "Indoleamine 2,3-dioxygenase (IDO), a tryptophan catabolizing enzyme, has been implicated in the pathogenesis of various neurological disorders. IDO expression is induced by IFN-gamma and leads to neurotoxicity by generating quinolinic acid. Additionally, it inhibits the immune response through both tryptophan depletion and generating other tryptophan catabolites. IL-4 and IL-13 have been shown to control IDO expression by antagonizing the effects of IFN-gamma in different cell types. Here, we investigated the effects of these cytokines on IDO expression in microglia. Interestingly, we observed that both IL-4 and IL-13 greatly enhanced IFN-gamma-induced IDO expression. However, tryptophanyl-tRNA synthetase (WRS), which is coinduced with IDO by IFN-gamma, is downregulated by IL-4 and IL-13. The effect of IL-4 and IL-13 was independent of STAT-6. Modulation of IDO but not WRS was eliminated by inhibition of protein phosphatase 2A (PP2A) activity. The phosphatidylinositol 3-kinase (PI3K) pathway further differentiated the regulation of these two enzymes, as inhibiting the PI3K pathway eliminated IFN-gamma induction of IDO, whereas such inhibition greatly enhanced WRS expression. These findings show discordance between modulations of expression of two distinct enzymes utilizing tryptophan as a common substrate, and raise the possibility of their involvement in regulating immune responses in various neurological disorders." @default.
- W2056556982 created "2016-06-24" @default.
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- W2056556982 creator A5091470496 @default.
- W2056556982 date "2007-07-27" @default.
- W2056556982 modified "2023-09-26" @default.
- W2056556982 title "IFN-γ-induced IDO and WRS expression in microglia is differentially regulated by IL-4" @default.
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- W2056556982 cites W1618814657 @default.
- W2056556982 cites W1749352888 @default.
- W2056556982 cites W1856702249 @default.
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- W2056556982 cites W2015220234 @default.
- W2056556982 cites W2015260577 @default.
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- W2056556982 doi "https://doi.org/10.1002/glia.20544" @default.
- W2056556982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2486430" @default.
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- W2056556982 hasPublicationYear "2007" @default.
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