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- W2056557400 abstract "The addition of Mg2+ caused marked increases in rat liver microsomal metabolism in vitro of several drug substrates. The substrates studied have been grouped according to the responses seen with increasing concentrations of Mg2+: (1) no effect or a decrease in enzyme activity; (2) increased enzyme activity with increased Mg2+ concentrations; and (3) peak enzyme activity with 6 mM Mg2+ or less, followed by a decreased activity with higher concentrations of Mg2+. Enhanced drug metabolism appeared to be caused by the Mg2+ ion rather than by ionic strength or associated anion. Although Mg2+ may affect the NADPH-generating system, it also enhanced the microsomal drug-metabolizing enzyme systems directly (Mg2+ enhanced activity in the absence of an NADPH-generating system). Other divalent cations (Mn2+, Ca2+ and Sr2+) caused a marked enhancement of hepatic microsomal metabolism similar to that caused by Mg2+ with all substrates studied. Divalent cobalt in low concentration caused enhanced microsomal metabolism of hexobarbital, but was inhibitory with other substrates. Ferrous ion, Cu2+ and Zn2+ did not enhance any of the microsomal drug metabolisms studied. The monovalent cations, K+ and Na+, had little if any effect on drug metabolism. The effects of the various cations studied were qualitatively the same with hepatic microsomal preparations from both control and phenobarbital-treated rats." @default.
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- W2056557400 title "The influence of magnesium and some other divalent cations on hepatic microsomal drug metabolism in vitro" @default.
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- W2056557400 doi "https://doi.org/10.1016/0006-2952(70)90210-8" @default.
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