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- W2056558699 abstract "To compare tissue concentrations of flurbiprofen resulting from topical application and oral administration according to the regulatory approved dosing guidelines.Sixteen patients were included in this study. Each patient was randomly assigned to the topical application or oral administration group. In each group, a pair of tapes or a tablet, containing a total of 40 mg flurbiprofen, was administered twice at 16 and 2 h before the surgery.The flurbiprofen concentration in the fat, tendon, muscle and periosteum tissues was significantly higher (P < 0.0330) after topical application (992 ng g⁻¹ [95% CI 482, 1503], 944 [95% CI 481, 1407], 492 [95% CI 248, 735], and 455 [95% CI 153, 756], respectively) than after oral administration (150 ng g⁻¹ [95% CI 84, 217], 186 [95% CI 118, 254], 82 [95% CI 49, 116],and 221 [95% CI, 135, 307], respectively).Topical application is an effective method to deliver flurbiprofen to the human body, particularly to soft tissues near the body surface." @default.
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- W2056558699 date "2013-02-05" @default.
- W2056558699 modified "2023-10-16" @default.
- W2056558699 title "Flurbiprofen concentration in soft tissues is higher after topical application than after oral administration" @default.
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- W2056558699 doi "https://doi.org/10.1111/j.1365-2125.2012.04394.x" @default.
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