FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056559464> ?p ?o ?g. }

• W2056559464 endingPage "1623" @default.
• W2056559464 startingPage "1617" @default.
• W2056559464 abstract "Genomic alterations affecting the 8q24 region are frequent in prostate cancer. Together with the oncogene MYC, other genes located in the surrounding of the amplified region could also be candidate targets. Tissue microarrays were constructed with prostate cancer tissues from (1) a case-control population of patients treated by radical prostatectomy (n = 242; 121 cases with biochemical relapse matched with 121 cancers with identical clinicopathologic features but without relapse), (2) castration-resistant disease (n = 55), and (3) metastatic cancers (n = 28). Fluorescence in situ hybridization and immunohistochemistry were used on tissue microarrays and slides to analyze, respectively, the amplification status of 8q24 and protein expression of genes located at 8q24. Amplification at the MYC locus was observed in 29% of cases and was closely associated with both disease progression (from 15% in pT2 tumors to 53% in metastasis; P = .001), and Gleason score (from <3% in Gleason 6 tumors to 66% in Gleason 8 and more tumors; P < .0001). The expression of genes located at 8q24 did not correlated with the amplification status, except for the Myc protein (P = .002). MYC amplification status but not Myc protein expression was significantly predictive of biochemical recurrence after prostatectomy, together with the proliferation marker Ki-67 and independently from known prognostic factors, including TNM stage and Gleason score. The MYC amplification status could constitute a useful prognostic tool for patients treated by radical prostatectomy, particularly for those with d'Amico intermediate risk, whose clinical behavior is currently difficult to predict." @default.
• W2056559464 created "2016-06-24" @default.
• W2056559464 creator A5010357609 @default.
• W2056559464 creator A5017481327 @default.
• W2056559464 creator A5025060290 @default.
• W2056559464 creator A5038667646 @default.
• W2056559464 creator A5050791373 @default.
• W2056559464 creator A5058284418 @default.
• W2056559464 creator A5066220603 @default.
• W2056559464 creator A5070605557 @default.
• W2056559464 date "2013-08-01" @default.
• W2056559464 modified "2023-09-25" @default.
• W2056559464 title "8q24 amplification is associated with Myc expression and prostate cancer progression and is an independent predictor of recurrence after radical prostatectomy" @default.
• W2056559464 cites W1547654062 @default.
• W2056559464 cites W1993584147 @default.
• W2056559464 cites W1995139299 @default.
• W2056559464 cites W2000191207 @default.
• W2056559464 cites W2012420343 @default.
• W2056559464 cites W2015437876 @default.
• W2056559464 cites W2030104557 @default.
• W2056559464 cites W2037743897 @default.
• W2056559464 cites W2044916117 @default.
• W2056559464 cites W2046709771 @default.
• W2056559464 cites W2049729002 @default.
• W2056559464 cites W2060899306 @default.
• W2056559464 cites W2072965928 @default.
• W2056559464 cites W2082030035 @default.
• W2056559464 cites W2086416171 @default.
• W2056559464 cites W2109897538 @default.
• W2056559464 cites W2133649938 @default.
• W2056559464 cites W2135798683 @default.
• W2056559464 cites W2153933760 @default.
• W2056559464 cites W2157043398 @default.
• W2056559464 cites W2158394122 @default.
• W2056559464 cites W2162147642 @default.
• W2056559464 cites W2172042768 @default.
• W2056559464 doi "https://doi.org/10.1016/j.humpath.2013.01.012" @default.
• W2056559464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23574779" @default.
• W2056559464 hasPublicationYear "2013" @default.
• W2056559464 type Work @default.
• W2056559464 sameAs 2056559464 @default.
• W2056559464 citedByCount "66" @default.
• W2056559464 countsByYear W20565594642013 @default.
• W2056559464 countsByYear W20565594642014 @default.
• W2056559464 countsByYear W20565594642015 @default.
• W2056559464 countsByYear W20565594642016 @default.
• W2056559464 countsByYear W20565594642017 @default.
• W2056559464 countsByYear W20565594642018 @default.
• W2056559464 countsByYear W20565594642019 @default.
• W2056559464 countsByYear W20565594642020 @default.
• W2056559464 countsByYear W20565594642021 @default.
• W2056559464 countsByYear W20565594642022 @default.
• W2056559464 countsByYear W20565594642023 @default.
• W2056559464 crossrefType "journal-article" @default.
• W2056559464 hasAuthorship W2056559464A5010357609 @default.
• W2056559464 hasAuthorship W2056559464A5017481327 @default.
• W2056559464 hasAuthorship W2056559464A5025060290 @default.
• W2056559464 hasAuthorship W2056559464A5038667646 @default.
• W2056559464 hasAuthorship W2056559464A5050791373 @default.
• W2056559464 hasAuthorship W2056559464A5058284418 @default.
• W2056559464 hasAuthorship W2056559464A5066220603 @default.
• W2056559464 hasAuthorship W2056559464A5070605557 @default.
• W2056559464 hasConcept C121608353 @default.
• W2056559464 hasConcept C126322002 @default.
• W2056559464 hasConcept C142724271 @default.
• W2056559464 hasConcept C143998085 @default.
• W2056559464 hasConcept C146357865 @default.
• W2056559464 hasConcept C151730666 @default.
• W2056559464 hasConcept C193270364 @default.
• W2056559464 hasConcept C204232928 @default.
• W2056559464 hasConcept C2776235491 @default.
• W2056559464 hasConcept C2777008409 @default.
• W2056559464 hasConcept C2779013556 @default.
• W2056559464 hasConcept C2779466945 @default.
• W2056559464 hasConcept C2780192828 @default.
• W2056559464 hasConcept C2781018059 @default.
• W2056559464 hasConcept C2908647359 @default.
• W2056559464 hasConcept C29537977 @default.
• W2056559464 hasConcept C502942594 @default.
• W2056559464 hasConcept C71924100 @default.
• W2056559464 hasConcept C86803240 @default.
• W2056559464 hasConcept C99454951 @default.
• W2056559464 hasConceptScore W2056559464C121608353 @default.
• W2056559464 hasConceptScore W2056559464C126322002 @default.
• W2056559464 hasConceptScore W2056559464C142724271 @default.
• W2056559464 hasConceptScore W2056559464C143998085 @default.
• W2056559464 hasConceptScore W2056559464C146357865 @default.
• W2056559464 hasConceptScore W2056559464C151730666 @default.
• W2056559464 hasConceptScore W2056559464C193270364 @default.
• W2056559464 hasConceptScore W2056559464C204232928 @default.
• W2056559464 hasConceptScore W2056559464C2776235491 @default.
• W2056559464 hasConceptScore W2056559464C2777008409 @default.
• W2056559464 hasConceptScore W2056559464C2779013556 @default.
• W2056559464 hasConceptScore W2056559464C2779466945 @default.
• W2056559464 hasConceptScore W2056559464C2780192828 @default.
• W2056559464 hasConceptScore W2056559464C2781018059 @default.
• W2056559464 hasConceptScore W2056559464C2908647359 @default.
• W2056559464 hasConceptScore W2056559464C29537977 @default.

• next