FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056559632> ?p ?o ?g. }

• W2056559632 endingPage "62" @default.
• W2056559632 startingPage "56" @default.
• W2056559632 abstract "Purpose of review Hypercapnia is a central component of current protective ventilatory strategies. This review aims to present and interpret data from recent clinical and experimental studies relating to hypercapnia and its role in protective ventilatory strategies. Recent findings Increasing clinical evidence supports the use of permissive hypercapnia, particularly in acute lung injury/acute respiratory distress syndrome, status asthmaticus, and neonatal respiratory failure. However, there are no clinical data examining the contribution of hypercapnia per se to protective ventilatory strategies. Recent experimental studies provide further support for the concept of therapeutic hypercapnia, whereby deliberately elevated PaCO2 may attenuate lung and systemic organ injury. CO2 administration attenuates experimental acute lung injury because of adverse ventilatory strategies, mesenteric ischemia reperfusion, and pulmonary endotoxin instillation. Hypercapnic acidosis attenuates key effectors of the inflammatory response and reduces lung neutrophil infiltration. At the genomic level, hypercapnic acidosis attenuates the activation of nuclear factor-κB, a key regulator of the expression of multiple genes involved in the inflammatory response. The physiologic effects of hypercapnia, both beneficial and potentially deleterious, are increasingly well understood. In addition, reports suggest that humans can tolerate extreme levels of hypercapnia for relatively prolonged periods without adverse effects. Summary The potential for hypercapnia to contribute to the beneficial effects of protective lung ventilatory strategies is clear from experimental studies. However, the optimal ventilatory strategy and the precise contribution of hypercapnia to this strategy remain unclear. A clearer understanding of its effects and mechanisms of action is central to determining the safety and therapeutic utility of hypercapnia in protective lung ventilatory strategies." @default.
• W2056559632 created "2016-06-24" @default.
• W2056559632 creator A5064700141 @default.
• W2056559632 creator A5072907843 @default.
• W2056559632 creator A5091498476 @default.
• W2056559632 date "2005-02-01" @default.
• W2056559632 modified "2023-10-17" @default.
• W2056559632 title "Permissive hypercapnia: role in protective lung ventilatory strategies" @default.
• W2056559632 cites W167331988 @default.
• W2056559632 cites W1881180115 @default.
• W2056559632 cites W1991606423 @default.
• W2056559632 cites W1992316135 @default.
• W2056559632 cites W2001490507 @default.
• W2056559632 cites W2002400430 @default.
• W2056559632 cites W2003546895 @default.
• W2056559632 cites W2015213242 @default.
• W2056559632 cites W2031561524 @default.
• W2056559632 cites W2035894832 @default.
• W2056559632 cites W2037913549 @default.
• W2056559632 cites W2038141609 @default.
• W2056559632 cites W2051271714 @default.
• W2056559632 cites W2052092902 @default.
• W2056559632 cites W2073336776 @default.
• W2056559632 cites W2073458790 @default.
• W2056559632 cites W2076135388 @default.
• W2056559632 cites W2084851916 @default.
• W2056559632 cites W2089934065 @default.
• W2056559632 cites W2092377873 @default.
• W2056559632 cites W2093285892 @default.
• W2056559632 cites W2096222719 @default.
• W2056559632 cites W2105902235 @default.
• W2056559632 cites W2117462978 @default.
• W2056559632 cites W2126687041 @default.
• W2056559632 cites W2133076568 @default.
• W2056559632 cites W2140651314 @default.
• W2056559632 cites W2142705676 @default.
• W2056559632 cites W2143748013 @default.
• W2056559632 cites W2144372305 @default.
• W2056559632 cites W2152366726 @default.
• W2056559632 cites W2158037105 @default.
• W2056559632 cites W2161607837 @default.
• W2056559632 cites W2162467169 @default.
• W2056559632 cites W2597070792 @default.
• W2056559632 cites W4230921159 @default.
• W2056559632 doi "https://doi.org/10.1097/00075198-200502000-00009" @default.
• W2056559632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15659946" @default.
• W2056559632 hasPublicationYear "2005" @default.
• W2056559632 type Work @default.
• W2056559632 sameAs 2056559632 @default.
• W2056559632 citedByCount "67" @default.
• W2056559632 countsByYear W20565596322012 @default.
• W2056559632 countsByYear W20565596322013 @default.
• W2056559632 countsByYear W20565596322014 @default.
• W2056559632 countsByYear W20565596322015 @default.
• W2056559632 countsByYear W20565596322016 @default.
• W2056559632 countsByYear W20565596322017 @default.
• W2056559632 countsByYear W20565596322018 @default.
• W2056559632 countsByYear W20565596322019 @default.
• W2056559632 countsByYear W20565596322020 @default.
• W2056559632 countsByYear W20565596322021 @default.
• W2056559632 countsByYear W20565596322022 @default.
• W2056559632 countsByYear W20565596322023 @default.
• W2056559632 crossrefType "journal-article" @default.
• W2056559632 hasAuthorship W2056559632A5064700141 @default.
• W2056559632 hasAuthorship W2056559632A5072907843 @default.
• W2056559632 hasAuthorship W2056559632A5091498476 @default.
• W2056559632 hasConcept C126322002 @default.
• W2056559632 hasConcept C177713679 @default.
• W2056559632 hasConcept C2776348555 @default.
• W2056559632 hasConcept C2777037550 @default.
• W2056559632 hasConcept C2777714996 @default.
• W2056559632 hasConcept C2778553927 @default.
• W2056559632 hasConcept C2780317664 @default.
• W2056559632 hasConcept C42219234 @default.
• W2056559632 hasConcept C71924100 @default.
• W2056559632 hasConceptScore W2056559632C126322002 @default.
• W2056559632 hasConceptScore W2056559632C177713679 @default.
• W2056559632 hasConceptScore W2056559632C2776348555 @default.
• W2056559632 hasConceptScore W2056559632C2777037550 @default.
• W2056559632 hasConceptScore W2056559632C2777714996 @default.
• W2056559632 hasConceptScore W2056559632C2778553927 @default.
• W2056559632 hasConceptScore W2056559632C2780317664 @default.
• W2056559632 hasConceptScore W2056559632C42219234 @default.
• W2056559632 hasConceptScore W2056559632C71924100 @default.
• W2056559632 hasIssue "1" @default.
• W2056559632 hasLocation W20565596321 @default.
• W2056559632 hasLocation W20565596322 @default.
• W2056559632 hasOpenAccess W2056559632 @default.
• W2056559632 hasPrimaryLocation W20565596321 @default.
• W2056559632 hasRelatedWork W1982433963 @default.
• W2056559632 hasRelatedWork W1993072600 @default.
• W2056559632 hasRelatedWork W2172037562 @default.
• W2056559632 hasRelatedWork W2285672337 @default.
• W2056559632 hasRelatedWork W2412014884 @default.
• W2056559632 hasRelatedWork W2497785827 @default.
• W2056559632 hasRelatedWork W3090738329 @default.
• W2056559632 hasRelatedWork W3168822392 @default.
• W2056559632 hasRelatedWork W4236818914 @default.

• next