FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056560010> ?p ?o ?g. }

• W2056560010 endingPage "20673" @default.
• W2056560010 startingPage "20664" @default.
• W2056560010 abstract "Cocoa was shown to inhibit chemically induced carcinogenesis in animals and exert antioxidant activity in humans. However, the molecular mechanisms of the chemopreventive potential of cocoa and its active ingredient(s) remain unknown. Here we report that cocoa procyanidins inhibit neoplastic cell transformation by suppressing the kinase activity of mitogen-activated protein kinase kinase (MEK). A cocoa procyanidin fraction (CPF) and procyanidin B2 at 5 mug/ml and 40 mum, respectively, inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic transformation of JB6 P+ mouse epidermal (JB6 P+) cells by 47 and 93%, respectively. The TPA-induced promoter activity and expression of cyclooxygenase-2, which is involved in tumor promotion and inflammation, were dose-dependently inhibited by CPF or procyanidin B2. The activation of activator protein-1 and nuclear factor-kappaB induced by TPA was also attenuated by CPF or procyanidin B2. The TPA-induced phosphorylation of MEK, extracellular signal-regulated kinase, and p90 ribosomal s6 kinase was suppressed by CPF or procyanidin B2. In vitro and ex vivo kinase assay data demonstrated that CPF or procyanidin B2 inhibited the kinase activity of MEK1 and directly bound with MEK1. CPF or procyanidin B2 suppressed JB6 P+ cell transformation induced by epidermal growth factor or H-Ras, both of which are known to be involved in MEK/ERK signal activation. In contrast, theobromine (up to 80 mum) had no effect on TPA-induced transformation, cyclooxygenase-2 expression, the transactivation of activator protein-1 or nuclear factor-kappaB, or MEK. Notably, procyanidin B2 exerted stronger inhibitory effects compared with PD098059 (a well known pharmacological inhibitor of MEK) on MEK1 activity and neoplastic cell transformation." @default.
• W2056560010 created "2016-06-24" @default.
• W2056560010 creator A5006050449 @default.
• W2056560010 creator A5022976734 @default.
• W2056560010 creator A5039473746 @default.
• W2056560010 creator A5051769949 @default.
• W2056560010 creator A5059470260 @default.
• W2056560010 creator A5074636897 @default.
• W2056560010 creator A5080925497 @default.
• W2056560010 date "2008-07-01" @default.
• W2056560010 modified "2023-10-12" @default.
• W2056560010 title "Cocoa Procyanidins Suppress Transformation by Inhibiting Mitogen-activated Protein Kinase Kinase" @default.
• W2056560010 cites W1482955429 @default.
• W2056560010 cites W1494491432 @default.
• W2056560010 cites W1964024317 @default.
• W2056560010 cites W1965037168 @default.
• W2056560010 cites W1965198668 @default.
• W2056560010 cites W1971915141 @default.
• W2056560010 cites W1989480480 @default.
• W2056560010 cites W2000170857 @default.
• W2056560010 cites W2002801265 @default.
• W2056560010 cites W2009379675 @default.
• W2056560010 cites W2011826559 @default.
• W2056560010 cites W2013589895 @default.
• W2056560010 cites W2016574982 @default.
• W2056560010 cites W2025424633 @default.
• W2056560010 cites W2029868005 @default.
• W2056560010 cites W2030174053 @default.
• W2056560010 cites W2035576433 @default.
• W2056560010 cites W2037952228 @default.
• W2056560010 cites W2040839454 @default.
• W2056560010 cites W2041094194 @default.
• W2056560010 cites W2053286013 @default.
• W2056560010 cites W2066022538 @default.
• W2056560010 cites W2073738021 @default.
• W2056560010 cites W2082773779 @default.
• W2056560010 cites W2087379913 @default.
• W2056560010 cites W2087509128 @default.
• W2056560010 cites W2088329401 @default.
• W2056560010 cites W2091446008 @default.
• W2056560010 cites W2091740389 @default.
• W2056560010 cites W2097795264 @default.
• W2056560010 cites W2100684141 @default.
• W2056560010 cites W2116554142 @default.
• W2056560010 cites W2118017964 @default.
• W2056560010 cites W2122172764 @default.
• W2056560010 cites W2130477740 @default.
• W2056560010 cites W2133830525 @default.
• W2056560010 cites W2146747271 @default.
• W2056560010 cites W2149169850 @default.
• W2056560010 cites W2154745788 @default.
• W2056560010 cites W2160991496 @default.
• W2056560010 cites W2338861111 @default.
• W2056560010 doi "https://doi.org/10.1074/jbc.m800263200" @default.
• W2056560010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2475700" @default.
• W2056560010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18519570" @default.
• W2056560010 hasPublicationYear "2008" @default.
• W2056560010 type Work @default.
• W2056560010 sameAs 2056560010 @default.
• W2056560010 citedByCount "71" @default.
• W2056560010 countsByYear W20565600102012 @default.
• W2056560010 countsByYear W20565600102013 @default.
• W2056560010 countsByYear W20565600102014 @default.
• W2056560010 countsByYear W20565600102015 @default.
• W2056560010 countsByYear W20565600102016 @default.
• W2056560010 countsByYear W20565600102017 @default.
• W2056560010 countsByYear W20565600102018 @default.
• W2056560010 countsByYear W20565600102019 @default.
• W2056560010 countsByYear W20565600102020 @default.
• W2056560010 countsByYear W20565600102021 @default.
• W2056560010 countsByYear W20565600102022 @default.
• W2056560010 countsByYear W20565600102023 @default.
• W2056560010 crossrefType "journal-article" @default.
• W2056560010 hasAuthorship W2056560010A5006050449 @default.
• W2056560010 hasAuthorship W2056560010A5022976734 @default.
• W2056560010 hasAuthorship W2056560010A5039473746 @default.
• W2056560010 hasAuthorship W2056560010A5051769949 @default.
• W2056560010 hasAuthorship W2056560010A5059470260 @default.
• W2056560010 hasAuthorship W2056560010A5074636897 @default.
• W2056560010 hasAuthorship W2056560010A5080925497 @default.
• W2056560010 hasBestOaLocation W20565600101 @default.
• W2056560010 hasConcept C104317684 @default.
• W2056560010 hasConcept C153911025 @default.
• W2056560010 hasConcept C170493617 @default.
• W2056560010 hasConcept C184235292 @default.
• W2056560010 hasConcept C185592680 @default.
• W2056560010 hasConcept C2778004101 @default.
• W2056560010 hasConcept C2993273003 @default.
• W2056560010 hasConcept C55493867 @default.
• W2056560010 hasConcept C555283112 @default.
• W2056560010 hasConcept C57074206 @default.
• W2056560010 hasConcept C70899900 @default.
• W2056560010 hasConcept C77784730 @default.
• W2056560010 hasConcept C86803240 @default.
• W2056560010 hasConcept C88045685 @default.
• W2056560010 hasConcept C90934575 @default.
• W2056560010 hasConcept C95444343 @default.
• W2056560010 hasConcept C97029542 @default.

• next