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• W2056560232 abstract "Arf GTPases are key regulators of both retrograde and anterograde traffic at the Golgi complex. The Golgi-localized Arf activators, Arf-GEFs (guanine exchange factor) of the BIG/GBF family, are poorly understood in terms of both their regulatory and localization mechanisms. We have performed a detailed kinetic characterization of a functional Golgi Arf-GEF, the trans-Golgi network (TGN)-localized Sec7 protein from yeast. We demonstrate that Sec7 is regulated by both autoinhibition and positive feedback. We show that positive feedback arises through the stable recruitment of Sec7 to membranes via its HDS1 domain by interaction with its product, activated Arf1. This interaction mediates localization of Sec7 to the TGN, because deletion of the HDS1 domain or mutation of the HDS1 domain in combination with deletion of Arf1 significantly increases cytoplasmic localization of Sec7. Our results lead us to propose a model in which Arf-GEF recruitment is linked to Golgi maturation via Arf1 activation." @default.
• W2056560232 created "2016-06-24" @default.
• W2056560232 creator A5014220267 @default.
• W2056560232 creator A5017460437 @default.
• W2056560232 creator A5051149977 @default.
• W2056560232 date "2012-04-01" @default.
• W2056560232 modified "2023-10-10" @default.
• W2056560232 title "The Sec7 Arf-GEF Is Recruited to the trans-Golgi Network by Positive Feedback" @default.
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• W2056560232 doi "https://doi.org/10.1016/j.devcel.2012.02.006" @default.
• W2056560232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3331996" @default.
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