FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056560260> ?p ?o ?g. }

• W2056560260 endingPage "111" @default.
• W2056560260 startingPage "103" @default.
• W2056560260 abstract "The neurofibromatosis type 1 (NF1) gene encodes a tumor suppressor protein, neurofibromin, which is expressed at high levels in Schwann cells and other adult tissues. Loss of NF1 expression has been reported in Schwann cell tumors (neurofibrosarcomas) from patients with NF1 and its loss is associated with increased proliferation of these cells. In this report, we describe downregulation of NF1 expression in a single spinal schwannoma from an individual without clinical features of neurofibromatosis type 1 or 2. Barely detectable expression of NF1 RNA was found in this tumor by in situ hybridization using an NF1-specific riboprobe as well as by Northern blot and reverse-transcribed (RT)-PCR analysis. In Schwann cells cultured from this schwannoma, abundant expression of NF1 RNA could be detected by Northern blot and RT-PCR analysis. These results suggest that, in some tumors, expression of NF1 may be downregulated by factors produced within the tumor and may represent a novel mechanism for inactivating these growth suppressing genes and allowing for increased cell proliferation in tumors." @default.
• W2056560260 created "2016-06-24" @default.
• W2056560260 creator A5025543314 @default.
• W2056560260 creator A5026858221 @default.
• W2056560260 creator A5039840081 @default.
• W2056560260 creator A5065106421 @default.
• W2056560260 creator A5070931319 @default.
• W2056560260 date "1995-01-01" @default.
• W2056560260 modified "2023-10-14" @default.
• W2056560260 title "Lack ofNF1 expression in a sporadic schwannoma from a patient without neurofibromatosis" @default.
• W2056560260 cites W1601342440 @default.
• W2056560260 cites W1912403151 @default.
• W2056560260 cites W1930700863 @default.
• W2056560260 cites W1963621662 @default.
• W2056560260 cites W1997914540 @default.
• W2056560260 cites W1999940194 @default.
• W2056560260 cites W2005149045 @default.
• W2056560260 cites W2020231002 @default.
• W2056560260 cites W2022329296 @default.
• W2056560260 cites W2027016720 @default.
• W2056560260 cites W2047614128 @default.
• W2056560260 cites W2049434359 @default.
• W2056560260 cites W2059986841 @default.
• W2056560260 cites W2066232674 @default.
• W2056560260 cites W2070491420 @default.
• W2056560260 cites W2071893342 @default.
• W2056560260 cites W2072478579 @default.
• W2056560260 cites W2079528978 @default.
• W2056560260 cites W2090369455 @default.
• W2056560260 cites W2090694642 @default.
• W2056560260 cites W2124735817 @default.
• W2056560260 cites W2161807488 @default.
• W2056560260 cites W2286377525 @default.
• W2056560260 cites W2412386425 @default.
• W2056560260 cites W4248543924 @default.
• W2056560260 doi "https://doi.org/10.1007/bf01057754" @default.
• W2056560260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8543966" @default.
• W2056560260 hasPublicationYear "1995" @default.
• W2056560260 type Work @default.
• W2056560260 sameAs 2056560260 @default.
• W2056560260 citedByCount "6" @default.
• W2056560260 countsByYear W20565602602020 @default.
• W2056560260 countsByYear W20565602602022 @default.
• W2056560260 crossrefType "journal-article" @default.
• W2056560260 hasAuthorship W2056560260A5025543314 @default.
• W2056560260 hasAuthorship W2056560260A5026858221 @default.
• W2056560260 hasAuthorship W2056560260A5039840081 @default.
• W2056560260 hasAuthorship W2056560260A5065106421 @default.
• W2056560260 hasAuthorship W2056560260A5070931319 @default.
• W2056560260 hasBestOaLocation W20565602602 @default.
• W2056560260 hasConcept C104317684 @default.
• W2056560260 hasConcept C127561419 @default.
• W2056560260 hasConcept C142724271 @default.
• W2056560260 hasConcept C150194340 @default.
• W2056560260 hasConcept C153911025 @default.
• W2056560260 hasConcept C170932241 @default.
• W2056560260 hasConcept C177707886 @default.
• W2056560260 hasConcept C2776415932 @default.
• W2056560260 hasConcept C2777004073 @default.
• W2056560260 hasConcept C2778264664 @default.
• W2056560260 hasConcept C2778837531 @default.
• W2056560260 hasConcept C2778984943 @default.
• W2056560260 hasConcept C2781447767 @default.
• W2056560260 hasConcept C502942594 @default.
• W2056560260 hasConcept C54355233 @default.
• W2056560260 hasConcept C555283112 @default.
• W2056560260 hasConcept C71924100 @default.
• W2056560260 hasConcept C81439078 @default.
• W2056560260 hasConcept C85265743 @default.
• W2056560260 hasConcept C86803240 @default.
• W2056560260 hasConcept C95444343 @default.
• W2056560260 hasConceptScore W2056560260C104317684 @default.
• W2056560260 hasConceptScore W2056560260C127561419 @default.
• W2056560260 hasConceptScore W2056560260C142724271 @default.
• W2056560260 hasConceptScore W2056560260C150194340 @default.
• W2056560260 hasConceptScore W2056560260C153911025 @default.
• W2056560260 hasConceptScore W2056560260C170932241 @default.
• W2056560260 hasConceptScore W2056560260C177707886 @default.
• W2056560260 hasConceptScore W2056560260C2776415932 @default.
• W2056560260 hasConceptScore W2056560260C2777004073 @default.
• W2056560260 hasConceptScore W2056560260C2778264664 @default.
• W2056560260 hasConceptScore W2056560260C2778837531 @default.
• W2056560260 hasConceptScore W2056560260C2778984943 @default.
• W2056560260 hasConceptScore W2056560260C2781447767 @default.
• W2056560260 hasConceptScore W2056560260C502942594 @default.
• W2056560260 hasConceptScore W2056560260C54355233 @default.
• W2056560260 hasConceptScore W2056560260C555283112 @default.
• W2056560260 hasConceptScore W2056560260C71924100 @default.
• W2056560260 hasConceptScore W2056560260C81439078 @default.
• W2056560260 hasConceptScore W2056560260C85265743 @default.
• W2056560260 hasConceptScore W2056560260C86803240 @default.
• W2056560260 hasConceptScore W2056560260C95444343 @default.
• W2056560260 hasIssue "2" @default.
• W2056560260 hasLocation W20565602601 @default.
• W2056560260 hasLocation W20565602602 @default.
• W2056560260 hasLocation W20565602603 @default.
• W2056560260 hasOpenAccess W2056560260 @default.
• W2056560260 hasPrimaryLocation W20565602601 @default.

• next