FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056560532> ?p ?o ?g. }

• W2056560532 endingPage "e3515" @default.
• W2056560532 startingPage "e3515" @default.
• W2056560532 abstract "Background Polyketides are a diverse group of biotechnologically important secondary metabolites that are produced by multi domain enzymes called polyketide synthases (PKS). Methodology/Principal Findings We have estimated frequencies of type I PKS (PKS I) – a PKS subgroup – in natural environments by using Hidden-Markov-Models of eight domains to screen predicted proteins from six metagenomic shotgun data sets. As the complex PKS I have similarities to other multi-domain enzymes (like those for the fatty acid biosynthesis) we increased the reliability and resolution of the dataset by maximum-likelihood trees. The combined information of these trees was then used to discriminate true PKS I domains from evolutionary related but functionally different ones. We were able to identify numerous novel PKS I proteins, the highest density of which was found in Minnesota farm soil with 136 proteins out of 183,536 predicted genes. We also applied the protocol to UniRef database to improve the annotation of proteins with so far unknown function and identified some new instances of horizontal gene transfer. Conclusions/Significance The screening approach proved powerful in identifying PKS I sequences in large sequence data sets and is applicable to many other protein families." @default.
• W2056560532 created "2016-06-24" @default.
• W2056560532 creator A5028929117 @default.
• W2056560532 creator A5042481507 @default.
• W2056560532 creator A5061955804 @default.
• W2056560532 creator A5074309419 @default.
• W2056560532 creator A5082134386 @default.
• W2056560532 date "2008-10-27" @default.
• W2056560532 modified "2023-10-14" @default.
• W2056560532 title "A Computational Screen for Type I Polyketide Synthases in Metagenomics Shotgun Data" @default.
• W2056560532 cites W1809713791 @default.
• W2056560532 cites W1910109602 @default.
• W2056560532 cites W1976773930 @default.
• W2056560532 cites W1992800126 @default.
• W2056560532 cites W1993631806 @default.
• W2056560532 cites W1998077837 @default.
• W2056560532 cites W2000176823 @default.
• W2056560532 cites W2001620437 @default.
• W2056560532 cites W2008133665 @default.
• W2056560532 cites W2011584519 @default.
• W2056560532 cites W2013619747 @default.
• W2056560532 cites W2027685090 @default.
• W2056560532 cites W2040077679 @default.
• W2056560532 cites W2059977778 @default.
• W2056560532 cites W2060425093 @default.
• W2056560532 cites W2063573248 @default.
• W2056560532 cites W2068687524 @default.
• W2056560532 cites W2074040006 @default.
• W2056560532 cites W2075716829 @default.
• W2056560532 cites W2076048958 @default.
• W2056560532 cites W2082315335 @default.
• W2056560532 cites W2082643924 @default.
• W2056560532 cites W2088109095 @default.
• W2056560532 cites W2096525273 @default.
• W2056560532 cites W2098023550 @default.
• W2056560532 cites W2103546861 @default.
• W2056560532 cites W2111373249 @default.
• W2056560532 cites W2113601822 @default.
• W2056560532 cites W2124010228 @default.
• W2056560532 cites W2124285343 @default.
• W2056560532 cites W2124637227 @default.
• W2056560532 cites W2124967403 @default.
• W2056560532 cites W2125178930 @default.
• W2056560532 cites W2126809954 @default.
• W2056560532 cites W2132926880 @default.
• W2056560532 cites W2136280642 @default.
• W2056560532 cites W2142925821 @default.
• W2056560532 cites W2145336165 @default.
• W2056560532 cites W2151831732 @default.
• W2056560532 cites W2158714788 @default.
• W2056560532 cites W2159243322 @default.
• W2056560532 cites W2167960671 @default.
• W2056560532 cites W2171777099 @default.
• W2056560532 cites W4230903726 @default.
• W2056560532 cites W4245082054 @default.
• W2056560532 doi "https://doi.org/10.1371/journal.pone.0003515" @default.
• W2056560532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2568958" @default.
• W2056560532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18953415" @default.
• W2056560532 hasPublicationYear "2008" @default.
• W2056560532 type Work @default.
• W2056560532 sameAs 2056560532 @default.
• W2056560532 citedByCount "30" @default.
• W2056560532 countsByYear W20565605322012 @default.
• W2056560532 countsByYear W20565605322013 @default.
• W2056560532 countsByYear W20565605322014 @default.
• W2056560532 countsByYear W20565605322015 @default.
• W2056560532 countsByYear W20565605322016 @default.
• W2056560532 countsByYear W20565605322017 @default.
• W2056560532 countsByYear W20565605322018 @default.
• W2056560532 countsByYear W20565605322022 @default.
• W2056560532 crossrefType "journal-article" @default.
• W2056560532 hasAuthorship W2056560532A5028929117 @default.
• W2056560532 hasAuthorship W2056560532A5042481507 @default.
• W2056560532 hasAuthorship W2056560532A5061955804 @default.
• W2056560532 hasAuthorship W2056560532A5074309419 @default.
• W2056560532 hasAuthorship W2056560532A5082134386 @default.
• W2056560532 hasBestOaLocation W20565605321 @default.
• W2056560532 hasConcept C104317684 @default.
• W2056560532 hasConcept C15151743 @default.
• W2056560532 hasConcept C167625842 @default.
• W2056560532 hasConcept C2776321320 @default.
• W2056560532 hasConcept C2777763344 @default.
• W2056560532 hasConcept C2778635478 @default.
• W2056560532 hasConcept C2781434637 @default.
• W2056560532 hasConcept C45484198 @default.
• W2056560532 hasConcept C54355233 @default.
• W2056560532 hasConcept C553450214 @default.
• W2056560532 hasConcept C70721500 @default.
• W2056560532 hasConcept C86803240 @default.
• W2056560532 hasConceptScore W2056560532C104317684 @default.
• W2056560532 hasConceptScore W2056560532C15151743 @default.
• W2056560532 hasConceptScore W2056560532C167625842 @default.
• W2056560532 hasConceptScore W2056560532C2776321320 @default.
• W2056560532 hasConceptScore W2056560532C2777763344 @default.
• W2056560532 hasConceptScore W2056560532C2778635478 @default.
• W2056560532 hasConceptScore W2056560532C2781434637 @default.
• W2056560532 hasConceptScore W2056560532C45484198 @default.
• W2056560532 hasConceptScore W2056560532C54355233 @default.

• next