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- W2056564289 abstract "Two types of effect of purines on the carbachol-induced contraction of the guinea-pig trachea in the presence or absence of glucose were evaluated using dipyridamole, an adenosine uptake inhibitor. ATP exerted a greater relaxant effect on the carbachol (10−6 M)-induced contraction than did adenosine in concentrations ranging from 10−4 to 10−3 M. These effects of purines were enhanced by pretreatment with dipyridamole (10−5 M) but were virtually unaffected by the purine receptor antagonists theophylline (10−5 M) and quinidine (10−5 M). The contraction evoked by carbachol was gradually reduced and was almost abolished 4–5 h after exposure to the glucose-free solution. This reduction was almost eliminated by readmitting glucose, and was restored to a certain degree by introducing ATP or adenosine. ATP was less effective than adenosine. This effect of purines but not that of glucose, was markedly diminished by pretreatment with dipyridamole (3 × 10−6 M to 10−5 M). The restoration of the carbachol-induced contraction following introduction of purines or glucose was completely antagonized by atropine (10−6 M). These results suggest that the extracellular effects of adenosine and ATP on the carbachol-induced contraction in normal solution are potentiated by dipyridamole, whereas the possible intracellular effects of these purines in the glucose-free solution are inhibited by this adenosine uptake inhibitor." @default.
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- W2056564289 title "Discrimination by dipyridamole of two types of responses to adenosine and ATP of the carbachol-induced contraction of guinea-pig trachea" @default.
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- W2056564289 doi "https://doi.org/10.1016/0014-2999(83)90210-8" @default.
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