FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056564326> ?p ?o ?g. }

• W2056564326 endingPage "520" @default.
• W2056564326 startingPage "515" @default.
• W2056564326 abstract "Zingiber officinale Rosc. (Zingiberaceae) has been traditionally used in Ayurvedic, Chinese and Tibb-Unani herbal medicines for the treatment of various illnesses that involve inflammation and which are caused by oxidative stress. Although gingerols and shogaols are the major bioactive compounds present in Zingiber officinale, their molecular mechanisms of actions and the relationship between their structural features and the activity have not been well studied. The aim of the present study was to examine and compare the antioxidant and anti-inflammatory activities of gingerols and their natural analogues to determine their structure–activity relationship and molecular mechanisms. The in vitro activities of the compounds [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol were evaluated for scavenging of 1,1-diphenyl-2-picyrlhydrazyl (DPPH), superoxide and hydroxyl radicals, inhibition of N-formyl-methionyl-leucyl-phenylalanine (f-MLP) induced reactive oxygen species (ROS) production in human polymorphonuclear neutrophils (PMN), inhibition of lipopolysaccharide induced nitrite and prostaglandin E2 production in RAW 264.7 cells. In the antioxidant activity assay, [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol exhibited substantial scavenging activities with IC50 values of 26.3, 19.47, 10.47 and 8.05 μM against DPPH radical, IC50 values of 4.05, 2.5, 1.68 and 0.85 μM against superoxide radical and IC50 values of 4.62, 1.97, 1.35 and 0.72 μM against hydroxyl radical, respectively. The free radical scavenging activity of these compounds also enhanced with increasing concentration (P < 0.05). On the other hand, all the compounds at a concentration of 6 μM have significantly inhibited (P < 0.05) f-MLP-stimulated oxidative burst in PMN. In addition, production of inflammatory mediators (NO and PGE2) has been inhibited significantly (P < 0.05) and dose-dependently. 6-Shogaol has exhibited the most potent antioxidant and anti-inflammatory properties which can be attributed to the presence of α,β-unsaturated ketone moiety. The carbon chain length has also played a significant role in making 10-gingerol as the most potent among all the gingerols. This study justifies the use of dry ginger in traditional systems of medicine." @default.
• W2056564326 created "2016-06-24" @default.
• W2056564326 creator A5027905237 @default.
• W2056564326 creator A5032768584 @default.
• W2056564326 creator A5034511488 @default.
• W2056564326 creator A5055490324 @default.
• W2056564326 creator A5060024728 @default.
• W2056564326 creator A5063107890 @default.
• W2056564326 date "2010-02-01" @default.
• W2056564326 modified "2023-10-16" @default.
• W2056564326 title "Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol" @default.
• W2056564326 cites W1550355974 @default.
• W2056564326 cites W1973018387 @default.
• W2056564326 cites W1981021151 @default.
• W2056564326 cites W1981714984 @default.
• W2056564326 cites W1981737096 @default.
• W2056564326 cites W1986627544 @default.
• W2056564326 cites W1986791595 @default.
• W2056564326 cites W1988150904 @default.
• W2056564326 cites W1989705993 @default.
• W2056564326 cites W1993377197 @default.
• W2056564326 cites W1998793303 @default.
• W2056564326 cites W2025265646 @default.
• W2056564326 cites W2028344952 @default.
• W2056564326 cites W2032013200 @default.
• W2056564326 cites W2033539243 @default.
• W2056564326 cites W2037279051 @default.
• W2056564326 cites W2045577822 @default.
• W2056564326 cites W2051061580 @default.
• W2056564326 cites W2061352029 @default.
• W2056564326 cites W2063012247 @default.
• W2056564326 cites W2069965813 @default.
• W2056564326 cites W2071255939 @default.
• W2056564326 cites W2132970107 @default.
• W2056564326 cites W2138562665 @default.
• W2056564326 cites W2949315205 @default.
• W2056564326 doi "https://doi.org/10.1016/j.jep.2009.10.004" @default.
• W2056564326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19833188" @default.
• W2056564326 hasPublicationYear "2010" @default.
• W2056564326 type Work @default.
• W2056564326 sameAs 2056564326 @default.
• W2056564326 citedByCount "521" @default.
• W2056564326 countsByYear W20565643262012 @default.
• W2056564326 countsByYear W20565643262013 @default.
• W2056564326 countsByYear W20565643262014 @default.
• W2056564326 countsByYear W20565643262015 @default.
• W2056564326 countsByYear W20565643262016 @default.
• W2056564326 countsByYear W20565643262017 @default.
• W2056564326 countsByYear W20565643262018 @default.
• W2056564326 countsByYear W20565643262019 @default.
• W2056564326 countsByYear W20565643262020 @default.
• W2056564326 countsByYear W20565643262021 @default.
• W2056564326 countsByYear W20565643262022 @default.
• W2056564326 countsByYear W20565643262023 @default.
• W2056564326 crossrefType "journal-article" @default.
• W2056564326 hasAuthorship W2056564326A5027905237 @default.
• W2056564326 hasAuthorship W2056564326A5032768584 @default.
• W2056564326 hasAuthorship W2056564326A5034511488 @default.
• W2056564326 hasAuthorship W2056564326A5055490324 @default.
• W2056564326 hasAuthorship W2056564326A5060024728 @default.
• W2056564326 hasAuthorship W2056564326A5063107890 @default.
• W2056564326 hasConcept C134550120 @default.
• W2056564326 hasConcept C181199279 @default.
• W2056564326 hasConcept C185592680 @default.
• W2056564326 hasConcept C2776039994 @default.
• W2056564326 hasConcept C2776151105 @default.
• W2056564326 hasConcept C2776778087 @default.
• W2056564326 hasConcept C2776789170 @default.
• W2056564326 hasConcept C2778004101 @default.
• W2056564326 hasConcept C2780795997 @default.
• W2056564326 hasConcept C2781401929 @default.
• W2056564326 hasConcept C2994357274 @default.
• W2056564326 hasConcept C31903555 @default.
• W2056564326 hasConcept C48349386 @default.
• W2056564326 hasConcept C55493867 @default.
• W2056564326 hasConcept C556039675 @default.
• W2056564326 hasConcept C71924100 @default.
• W2056564326 hasConcept C98274493 @default.
• W2056564326 hasConceptScore W2056564326C134550120 @default.
• W2056564326 hasConceptScore W2056564326C181199279 @default.
• W2056564326 hasConceptScore W2056564326C185592680 @default.
• W2056564326 hasConceptScore W2056564326C2776039994 @default.
• W2056564326 hasConceptScore W2056564326C2776151105 @default.
• W2056564326 hasConceptScore W2056564326C2776778087 @default.
• W2056564326 hasConceptScore W2056564326C2776789170 @default.
• W2056564326 hasConceptScore W2056564326C2778004101 @default.
• W2056564326 hasConceptScore W2056564326C2780795997 @default.
• W2056564326 hasConceptScore W2056564326C2781401929 @default.
• W2056564326 hasConceptScore W2056564326C2994357274 @default.
• W2056564326 hasConceptScore W2056564326C31903555 @default.
• W2056564326 hasConceptScore W2056564326C48349386 @default.
• W2056564326 hasConceptScore W2056564326C55493867 @default.
• W2056564326 hasConceptScore W2056564326C556039675 @default.
• W2056564326 hasConceptScore W2056564326C71924100 @default.
• W2056564326 hasConceptScore W2056564326C98274493 @default.
• W2056564326 hasIssue "2" @default.
• W2056564326 hasLocation W20565643261 @default.
• W2056564326 hasLocation W20565643262 @default.

• next