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- W2056564453 abstract "We investigated peroxisome proliferator-activated receptor- γ (PPAR- γ ) ligands effect on cell motility and the plasminogen activator system using normal MCF-10A and malignant MCF-10CA1 cell lines. Ciglitazone reduced both wound-induced migration and chemotaxis. However, the effect was not reversed with pretreatment of cells with the PPAR- γ -specific antagonist GW9662. Immunoblot analysis of conditioned media showed ciglitazone decreased plasminogen activator inhibitor-1 (PAI-1) in both cell lines; this effect was also unaltered by PPAR- γ antagonism. Alternatively, treatment with the ω -6 fatty acid arachidonic acid (ArA), but not the ω -3 fatty acid docosahexanoic acid, increased both MCF-10A cell migration and cell surface uPA activity. Pretreatment with a PPAR- γ antagonist reversed these effects, suggesting that ArA mediates its effect on cell motility and uPA activity through PPAR- γ activation. Collectively, the data suggest PPAR- γ ligands have a differential effect on normal and malignant cell migration and the plasminogen activation system, resulting from PPAR- γ -dependent and PPAR- γ -independent effects." @default.
- W2056564453 created "2016-06-24" @default.
- W2056564453 creator A5073856682 @default.
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- W2056564453 date "2011-01-01" @default.
- W2056564453 modified "2023-10-15" @default.
- W2056564453 title "Peroxisome Proliferator-Activated Receptor-γLigands Alter Breast Cancer Cell Motility through Modulation of the Plasminogen Activator System" @default.
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- W2056564453 doi "https://doi.org/10.1155/2011/594258" @default.
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