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- W2056565195 abstract "Cells of the murine plasmacytoid line MOPC-315 synthesize two distinct immunoglobulin light chains: a normal lambda II protein, which is incorporated into secretory and surface-bound immunoglobulin, and a truncated, nonfunctional lambda I protein found only in the cytoplasm. Idiotype-specific suppressor T lymphocytes selectively inhibit the expression of both lambda II- and lambda I-specific messenger RNA by MOPC-315 cells. This finding demonstrates that phenotypically excluded light chain genes can be subject to immunoregulatory control and suggests that the expression of divergent lambda isotypes may be coordinately regulated in immunoglobulin-secreting cells." @default.
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- W2056565195 date "1983-06-24" @default.
- W2056565195 modified "2023-09-26" @default.
- W2056565195 title "Suppressor T cell action inhibits the expression of an excluded immunoglobulin gene" @default.
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- W2056565195 doi "https://doi.org/10.1126/science.6222474" @default.
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