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• W2056566150 endingPage "930" @default.
• W2056566150 startingPage "921" @default.
• W2056566150 abstract "The mechanism of amylase and sialic acid releases stimulated by pilocarpine or high K+ medium was investigated in the slices of dog submandibular glands. The release of both amylase and sialic acid was dose-dependently increased by pilocarpine and a considerable release was observed at pilocarpine concentrations of more than 1 microM. Similar effects were observed when K+ concentration in the medium was increased and the maximal response was observed at 75 mM K+. The release of amylase and sialic acid by pilocarpine or K+ considerably decreased by removing Ca2+ from the medium and the slices. The release of amylase in the Ca2+-deficient slices was nearly recovered by the addition of 2.5 and 5.0 mM Ca2+, whereas that of sialic acid was recovered by only 60-75%. Ca2+ inhibitors, La3+ and verapamil, and calmodulin inhibitors, trifluoperazine, prenylamine, and W-7, significantly inhibited the release of amylase and sialic acid induced by the stimulants. These results suggest that the release of amylase and sialic acid stimulated by pilocarpine or K+ is dependent on the presence of Ca2+, and that the activation of calmodulin is involved in the process of the release." @default.
• W2056566150 created "2016-06-24" @default.
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• W2056566150 date "1983-01-01" @default.
• W2056566150 modified "2023-09-26" @default.
• W2056566150 title "Stimulation of amylase and sialic acid releases from dog submandibular gland slices by pilocarpine or high K+ medium: A possible role of calmodulin for their releases." @default.
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• W2056566150 doi "https://doi.org/10.2170/jjphysiol.33.921" @default.
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• W2056566150 hasPublicationYear "1983" @default.
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