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- W2056566535 endingPage "823" @default.
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- W2056566535 abstract "Biomechanical factors play an important role in the health of diarthrodial joints. Altered joint loading – associated to obesity, malalignment, trauma or joint instability – is a critical risk factor for joint degeneration, whereas exercise and weight loss have generally been shown to promote beneficial effects for osteoarthritic joints. The mechanisms by which mechanical stress alters the physiology or pathophysiology of articular cartilage or other joint tissues likely involve complex interactions with genetic and molecular influences, particularly local or systemic inflammation secondary to injury or obesity. Chondrocytes perceive physical signals from their environment using a variety of mechanisms, including ion channels, integrin-mediated connections to the extracellular matrix that involve membrane, cytoskeletal and intracellular deformation. An improved understanding of the biophysical and molecular pathways involved in chondrocyte mechanotransduction can provide insight into the development of novel therapeutic approaches for osteoarthritis." @default.
- W2056566535 created "2016-06-24" @default.
- W2056566535 creator A5090627153 @default.
- W2056566535 date "2011-12-01" @default.
- W2056566535 modified "2023-10-17" @default.
- W2056566535 title "Biomechanical factors in osteoarthritis" @default.
- W2056566535 cites W113490097 @default.
- W2056566535 cites W1607875640 @default.
- W2056566535 cites W1712309657 @default.
- W2056566535 cites W1801949341 @default.
- W2056566535 cites W1885184852 @default.
- W2056566535 cites W1963813826 @default.
- W2056566535 cites W1964038634 @default.
- W2056566535 cites W1964596059 @default.
- W2056566535 cites W1964836517 @default.
- W2056566535 cites W1965282306 @default.
- W2056566535 cites W1966686938 @default.
- W2056566535 cites W1967031104 @default.
- W2056566535 cites W1967657670 @default.
- W2056566535 cites W1968402436 @default.
- W2056566535 cites W1969221593 @default.
- W2056566535 cites W1969830786 @default.
- W2056566535 cites W1970693983 @default.
- W2056566535 cites W1974640471 @default.
- W2056566535 cites W1976797469 @default.
- W2056566535 cites W1980157244 @default.
- W2056566535 cites W1986841296 @default.
- W2056566535 cites W1988682659 @default.
- W2056566535 cites W1991532350 @default.
- W2056566535 cites W1991987132 @default.
- W2056566535 cites W1994366307 @default.
- W2056566535 cites W1994906315 @default.
- W2056566535 cites W1998785004 @default.
- W2056566535 cites W1999158053 @default.
- W2056566535 cites W1999893828 @default.
- W2056566535 cites W2001945348 @default.
- W2056566535 cites W2002250615 @default.
- W2056566535 cites W2002251686 @default.
- W2056566535 cites W2002780234 @default.
- W2056566535 cites W2007029906 @default.
- W2056566535 cites W2009350275 @default.
- W2056566535 cites W2010313836 @default.
- W2056566535 cites W2010335941 @default.
- W2056566535 cites W2011227409 @default.
- W2056566535 cites W2011454589 @default.
- W2056566535 cites W2015906476 @default.
- W2056566535 cites W2017435196 @default.
- W2056566535 cites W2026214364 @default.
- W2056566535 cites W2026420278 @default.
- W2056566535 cites W2033538734 @default.
- W2056566535 cites W2034201007 @default.
- W2056566535 cites W2038407070 @default.
- W2056566535 cites W2041676787 @default.
- W2056566535 cites W2044474278 @default.
- W2056566535 cites W2047877478 @default.
- W2056566535 cites W2051165214 @default.
- W2056566535 cites W2052989439 @default.
- W2056566535 cites W2054358856 @default.
- W2056566535 cites W2054388804 @default.
- W2056566535 cites W2054398590 @default.
- W2056566535 cites W2060431825 @default.
- W2056566535 cites W2063045388 @default.
- W2056566535 cites W2064491404 @default.
- W2056566535 cites W2064880478 @default.
- W2056566535 cites W2066109281 @default.
- W2056566535 cites W2071823815 @default.
- W2056566535 cites W2074087706 @default.
- W2056566535 cites W2074524774 @default.
- W2056566535 cites W2077741258 @default.
- W2056566535 cites W2079181720 @default.
- W2056566535 cites W2092509345 @default.
- W2056566535 cites W2092868973 @default.
- W2056566535 cites W2095028617 @default.
- W2056566535 cites W2103953939 @default.
- W2056566535 cites W2114736265 @default.
- W2056566535 cites W2115685969 @default.
- W2056566535 cites W2121801199 @default.
- W2056566535 cites W2126579463 @default.
- W2056566535 cites W2129355235 @default.
- W2056566535 cites W2130766522 @default.
- W2056566535 cites W2131347621 @default.
- W2056566535 cites W2142259793 @default.
- W2056566535 cites W2142617116 @default.
- W2056566535 cites W2155936356 @default.
- W2056566535 cites W2158535455 @default.
- W2056566535 cites W2163135881 @default.
- W2056566535 cites W2166354163 @default.
- W2056566535 cites W2168114618 @default.
- W2056566535 cites W2171233986 @default.
- W2056566535 cites W2309357188 @default.
- W2056566535 cites W3025829724 @default.
- W2056566535 cites W4234984997 @default.
- W2056566535 cites W4247974962 @default.
- W2056566535 cites W4251915066 @default.
- W2056566535 cites W4318470584 @default.
- W2056566535 doi "https://doi.org/10.1016/j.berh.2011.11.013" @default.
- W2056566535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3266544" @default.
- W2056566535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22265263" @default.