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- W2056567462 abstract "In addition to the correlation of transforming growth factor (TGF)-beta1 levels to the radiation toxicity, both Epstein-Barr virus (EBV) infection and postoperative status play roles in the change in plasma TGF-beta1 levels in patients with head and neck cancers.To assess the parameters involved in the change in plasma TGF-beta1 level during concurrent chemoradiotherapy (CCRT).Blood samples (n=307) before, during, and after treatment were obtained from 39 patients with head and neck cancers treated with definitive or adjuvant CCRT. In situ hybridization (ISH) was used to identify EBV-encoded RNA (EBER) in tissues from the primary tumor or metastatic lymph nodes. Plasma TGF-beta1 level, white blood cell (WBC), and platelet count were assayed immediately before the first fraction of radiotherapy (RT), once a week during RT, and at the end of the RT course. The grades of mucositis and dermatitis were recorded weekly during CCRT.Pretreatment TGF-beta1 level and radiation toxicity were found to be significantly correlated with the increase of the plasma TGF-beta1 level during CCRT (p<0.05), but correlation of platelet count was only found in patients whose tumors were EBV-positive (p=0.0042), and WBC count in those treated with postoperative adjuvant CCRT (p=0.004)." @default.
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- W2056567462 date "2008-01-01" @default.
- W2056567462 modified "2023-09-26" @default.
- W2056567462 title "Epstein–Barr virus infection and plasma transforming growth factor-β1 levels in head and neck cancers" @default.
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- W2056567462 doi "https://doi.org/10.1080/00016480701714293" @default.
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