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- W2056568234 abstract "Thrombin stimulates both DNA synthesis and cell morphological changes in Swiss 3T3 cells, although the mechanism of signal coordination leading to these responses is unknown. We report here that nitric oxide (NO) donors selectively enhance thrombin-stimulated p70(S6k) activity by 40-60%, an effect that was sustained for 24 h. Potentiation of p70(S6k) also was observed with cGMP analogues indicating that this effect is mediated by cGMP-activated protein kinase. NO donors also induced morphological changes characterized by spindle-shaped cells in confluent, nondividing cells or by extended protrusions from the trailing edge in subconfluent, polarized cells. NO donors had no significant effects on intracellular Ca(2+) mobilization, DNA synthesis, proliferation, or ERKs 1 and 2 and p90RSK activities, indicating that mitogenic responses and cell division are not altered by NO donors. We conclude that NO donors modulate the morphological changes associated with cellular motility in response to thrombin stimulation through selective enhancement of p70(S6k) activity." @default.
- W2056568234 created "2016-06-24" @default.
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- W2056568234 date "1999-12-01" @default.
- W2056568234 modified "2023-10-10" @default.
- W2056568234 title "Nitric Oxide Donors Selectively Potentiate Thrombin-Stimulated p70S6k Activity and Morphological Changes in Swiss 3T3 Cells" @default.
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- W2056568234 doi "https://doi.org/10.1006/bbrc.1999.1833" @default.
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