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- W2056568275 abstract "To assess cortical development (CD) and corpus callosum (CC) differences by fetal MRI in a cohort of term small fetuses and controls, and to evaluate their predictive value of an abnormal neurodevelopment at 2 years. 60 small fetuses and 42 controls underwent a fetal brain MRI scan at 37 weeks to assess CD and CC morphometry. At two years of age, Bayley III (B-III) scale test for infant and toddler development was performed in the whole sample to evaluate their cognitive, language, motor, social-emotional and adaptive competencies. Results from B-III test were considered abnormal if one or more domains had a score <85. The predictive value of CD and CC was assessed by means of bivariate correlations and logistic regressions adjusting by gender, ma-ternal socio-economic status, breastfeeding and age at the B-III test. Small fetuses showed deeper fissures, thinner cortical thickness and smaller CC. They also presented significantly worse scores in the cognitive, language and motor domains from the B-III test when compared to controls. CD and CC measurements showed a negative correlation with B-III test scores, which were particularly significant in several of the CC areas. Finally, after using a principal component analysis, posterior callosal midbody area, CC length and right lateral fissure depth were selected and a composite score using these variables was constructed. Our composite score showed a significant predictive value for an abnormal neurodevelopment in this sample. Fetal CD and CC morphometry at term have the potential to predict an abnormal neurodevelopment and their role as image biomarkers should be further investigated." @default.
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- W2056568275 date "2014-09-01" @default.
- W2056568275 modified "2023-10-06" @default.
- W2056568275 title "OC20.01: Fetal brain cortical development and corpus callosum morphometry assessed by MRI as predictors of an abnormal neurodevelopment outcome at 2 years of age in term small for gestational age-born infants" @default.
- W2056568275 doi "https://doi.org/10.1002/uog.13590" @default.
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