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• W2056569074 endingPage "655" @default.
• W2056569074 startingPage "643" @default.
• W2056569074 abstract "The mesodermally derived normal ovarian surface epithelium (OSE) displays both epithelial and mesenchymal characteristics and exhibits remarkable phenotypic plasticity during post-ovulatory repair. The majority of epithelial ovarian carcinomas (EOC) are derived from the OSE and represent the most lethal of all gynecological malignancies, as most patients (approximately 70%) present at diagnosis with disseminated intra-abdominal metastasis. The predominant pattern of EOC metastasis involves pelvic dissemination rather than lymphatic or hematologic spread, distinguishing EOC from other solid tumors. Acquisition of the metastatic phenotype involves a complex series of interrelated cellular events leading to dissociation (shedding) and dispersal of malignant cells. A key event in this process is disruption of cell-cell contacts via modulation of intercellular junctional components. In contrast to most carcinomas that downregulate E-cadherin expression during tumor progression, a unique feature of primary well-differentiated ovarian cancers is a gain of epithelial features, characterized by an increase in expression of E-cadherin. Subsequent reacquisition of mesenchymal features is observed in more advanced tumors with concomitant loss of E-cadherin expression and/or function during progression to metastasis. The functional consequences of this remarkable phenotypic plasticity are not fully understood, but may play a role in modulation of cell survival in suspension (ascites), chemoresistance, and intraperitoneal anchoring of metastatic lesions." @default.
• W2056569074 created "2016-06-24" @default.
• W2056569074 creator A5034090671 @default.
• W2056569074 creator A5044838085 @default.
• W2056569074 creator A5068267413 @default.
• W2056569074 date "2008-04-09" @default.
• W2056569074 modified "2023-10-05" @default.
• W2056569074 title "Phenotypic plasticity of neoplastic ovarian epithelium: unique cadherin profiles in tumor progression" @default.
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