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- W2056569119 abstract "Quantitative immunofluorescence tests were used to study MTV-antigen production in normal and mammary tumor-bearing mice of two low (BALB/c and C3Hf) and two high (C3H and GR) mammary cancer strains. Mammary tumors could be distinguished on the basis of MTV-antigen expression in two groups; (1) a group of positive and (2) a group of negative tumors occurring in BALB/c mice. While the tumors of the first group in this study were all adenocarcinomas, the tumors of the second group were adenoacanthomas. MTV-antigen production was comparatively high in tumors of the C3Hf and C3H strains, as well as in the MTV-induced tumors of the BALB/c strain, but low in GR-strain tumors. Sera from mice bearing MTV-antigen producing mammary tumors (as well as from some pregnant and lactating GR mice) contained excess MTV-antigens. Spleens of BALB/c mice bearing MTV-antigen-induced tumors often contained detectable amounts of MTV-antigens, while normal and mammary tumor-bearing C3Hf and C3H mice also occasionally showed detectable amounts of MTV-antigens in their spleens. In contrast, spleens of GR mice were always MTV-antigen negative by immunofluorescence absorption tests. Thymuses, livers and kidneys of the various strains tested were invariably negative." @default.
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- W2056569119 date "1973-11-15" @default.
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- W2056569119 title "Mammary tumor virus (MTV) antigens in normal and mammary tumor-bearing mice" @default.
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- W2056569119 doi "https://doi.org/10.1002/ijc.2910120305" @default.
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